Adverse events (collected over the course of the studies; they are not measured/reported for specific time points) · People with fungal infections of the toenails
It is very uncertain whether 1064‐nm Nd:YAG laser changes adverse events (collected over the course of the studies; they are… compared with no treatment or sham treatment (very low certainty).
1 finding from 1 review
Mycological cure · People with fungal infections of the toenails
1064‐nm Nd:YAG laser showed no clear difference in mycological cure: 52 weeks compared with no treatment or sham treatment (low certainty).
1 finding from 1 review
Clinical cure ‐ not measured · People with fungal infections of the toenails
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Scar severity ‐ Neodymium‐doped yttrium aluminium garnet (Nd:YAG) laser plus Diprospan plus 5‐FU versus Diprospan plus 5‐FU ‐ blinded observer assessment of good to excellent scar improvement ‐ keloid scars ‐ · participants with hypertrophic and keloid scars
It is very uncertain whether laser therapy plus other treatment changes scar severity ‐ Neodymium‐doped yttrium aluminium garnet (Nd:YAG)… compared with other treatment (very low certainty).
1 finding from 1 review
RR 1.45 [0.88, 2.41]
Studies not reported
Very low
Marginal integrity of restoration · Children, adolescents and adults with caries in deciduous and permanent teeth (age 3.5 to 84 years)
Laser (Er:YAG, Er,Cr:YSGG, or Nd:YAG) showed no clear difference in marginal integrity of restorations compared with conventional mechanical caries removal (standard drill; handpiece…; GRADE not reported.
3 findings from 1 review
Participant discomfort (vibration, smell, noise) · Children, adolescents and adults with caries in deciduous and permanent teeth (age 3.5 to 84 years)
1 finding from 1 review
Pulpal inflammation or necrosis · Children, adolescents and adults with caries in deciduous and permanent teeth (age 3.5 to 84 years)
It is very uncertain whether laser (Er:YAG, Er,Cr:YSGG, or Nd:YAG) changes pulpal inflammation or necrosis compared with conventional mechanical caries removal (standard drill; handpiece… (very low certainty).
3 findings from 1 review
Restoration survival · Children, adolescents and adults with caries in deciduous and permanent teeth (age 3.5 to 84 years)
It is very uncertain whether laser (Er:YAG, Er,Cr:YSGG, or Nd:YAG) changes durability of restoration compared with conventional mechanical caries removal (standard drill; handpiece… (very low certainty).
3 findings from 1 review
Operator preference/fatigue in operator · Children, adolescents and adults with caries in deciduous and permanent teeth (age 3.5 to 84 years)
1 finding from 1 review
Caries removal (clinical) · Children, adolescents and adults with caries in deciduous and permanent teeth (age 3.5 to 84 years)
Laser (Er:YAG, Er,Cr:YSGG, or Nd:YAG) showed no clear difference in caries removal (clinical) compared with conventional mechanical caries removal (standard drill; handpiece… (low certainty).
1 finding from 1 review
Duration of treatment · Children, adolescents and adults with caries in deciduous and permanent teeth (age 3.5 to 84 years)
Laser (Er:YAG, Er,Cr:YSGG, or Nd:YAG) led to higher duration of treatment compared with conventional mechanical caries removal (standard drill; handpiece…; GRADE not reported.
1 finding from 1 review
MD 0.90 [0.59, 1.21]
4 studies
GRADE not reported
Laser (Er:YAG, Er,Cr:YSGG, or Nd:YAG) vs Other caries removal systems (chemo-mechanical, sono-abrasion, or air-abrasion)
Outcome not reported · Children, adolescents and adults with caries in deciduous and permanent teeth (age 3.5 to 84 years)
The review found no eligible studies for this question.
1 finding from 1 review
'Types of interventions' allowed comparison of laser with other caries-removal systems (chemo-mechanical, sono-abrasion, air-abrasion); no included study used such a comparator (all nine included trials compared laser…
Studies not reported
No studies found
Secondary caries · Children, adolescents and adults with caries in deciduous and permanent teeth (age 3.5 to 84 years)
1 finding from 1 review
Participant preference · Children, adolescents and adults with caries in deciduous and permanent teeth (age 3.5 to 84 years)
1 finding from 1 review
Three studies (Evans 2000; Liu 2006; Zhang 2013) reported participants' preference for future treatment. Zhang 2013: 37/53 children (72%) preferred laser, 10 (22%) drill. Liu 2006: 36/40 (90%) preferred laser, 4 (5%)…
3 studies
GRADE not reported
Episodes of pain (moderate or high pain; six-face rating scale) · Children, adolescents and adults with caries in deciduous and permanent teeth (age 3.5 to 84 years)
Laser (Er:YAG, Er,Cr:YSGG, or Nd:YAG) may leads to lower episodes of pain (moderate or high pain; six-face rating scale) compared with conventional mechanical caries removal (standard drill; handpiece… (low certainty).
1 finding from 1 review
Need for anaesthesia · Children, adolescents and adults with caries in deciduous and permanent teeth (age 3.5 to 84 years)
Laser (Er:YAG, Er,Cr:YSGG, or Nd:YAG) led to lower need for anaesthesia compared with conventional mechanical caries removal (standard drill; handpiece…; GRADE not reported.
2 findings from 1 review
HRQOL ‐ not measured · Participants with rosacea
The review found no eligible studies for this question.
1 finding from 1 review
Participant‐assessed improvement in rosacea severity · Participants with rosacea
1 finding from 1 review
Proportion of participants with adverse event1 Pain as assessed by VAS (0 to 10; higher score is worse) · Participants with rosacea
1 finding from 1 review
Physician‐assessed improvement in rosacea severity ‐ not measured · Participants with rosacea
The review found no eligible studies for this question.
1 finding from 1 review