Findings

What do systematic reviews say?

53 questions · 60 findings · 4 reviews

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No studies found 34 · 56.7%GRADE not reported 3 · 5%Very low 14 · 23.3%Low 8 · 13.3%Moderate 1 · 1.7%High 0 · 0%

NPWT vs dressings

Wound recurrence · treating foot wounds in people with diabetes mellitus

It is very uncertain whether NPWT changes wound recurrence compared with dressings (very low certainty).

2 findings from 1 review

Negative pressure wound therapy for treating foot wounds in people with diabetes mellitus 2018 · Cochrane Headline outcomes only
RR 0.5 [0.1, 2.53]
1 study · 60 participants
Very low
Negative pressure wound therapy for treating foot wounds in people with diabetes mellitus 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT vs dressings

Ulcer healing · treating foot wounds in people with diabetes mellitus

NPWT may leads to higher time to healing compared with dressings (low certainty).

2 findings from 1 review

Negative pressure wound therapy for treating foot wounds in people with diabetes mellitus 2018 · Cochrane Headline outcomes only
HR 1.91 [1.21, 2.99]
1 study · 162 participants
Low
Negative pressure wound therapy for treating foot wounds in people with diabetes mellitus 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 468 participants
Low

NPWT 125 mmHg vs NPWT 75 mmHg

Complete wound healing · other open traumatic wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 125 mmHg vs NPWT 75 mmHg

Wound infection · other open traumatic wounds

It is very uncertain whether NPWT 125 mmHg changes wound infection compared with NPWT 75 mmHg (very low certainty).

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
RR 1.04 [0.31, 3.51]
1 study · 251 participants
Very low

NPWT 125 mmHg vs NPWT 75 mmHg

Adverse events · other open traumatic wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 125 mmHg vs NPWT 75 mmHg

Time to closure or coverage surgery · other open traumatic wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 125 mmHg vs NPWT 75 mmHg

Pain · other open traumatic wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 75 mmHg vs usual care

Complete wound healing · other open traumatic wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 75 mmHg vs usual care

Wound infection · other open traumatic wounds

It is very uncertain whether NPWT 75 mmHg changes wound infection compared with standard care (very low certainty).

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
RR 0.44 [0.17, 1.1]
1 study · 463 participants
Very low

NPWT 75 mmHg vs usual care

Adverse events · other open traumatic wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 75 mmHg vs usual care

Time to closure or coverage surgery · other open traumatic wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 75 mmHg vs usual care

Pain · other open traumatic wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 125 mmHg vs usual care

Complete wound healing · open fracture wounds

NPWT 125 mmHg showed no clear difference in complete wound healing compared with standard care (moderate certainty).

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
RR 1.01 [0.81, 1.27]
1 study · 460 participants
Moderate

NPWT 125 mmHg vs usual care

Patient‐reported pain intensity or pain relief (VAS, NRS or categorical scale) · other open traumatic wounds

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 51 participants
Low

NPWT 125 mmHg vs usual care

Wound infection · open fracture wounds

It is very uncertain whether NPWT 125 mmHg changes wound infection compared with standard care (very low certainty).

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
RR 0.48 [0.2, 1.13]
4 studies · 596 participants
Very low

NPWT 125 mmHg vs usual care

Adverse events · open fracture wounds

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 460 participants
GRADE not reported

NPWT 125 mmHg vs usual care

Time to closure or coverage surgery · open fracture wounds

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 151 participants
Very low

NPWT 125 mmHg vs usual care

Pain · open fracture wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 125 mmHg vs usual care

Complete wound healing · other open traumatic wounds

The review found no eligible studies for this question.

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NPWT 125 mmHg vs usual care

Wound infection · other open traumatic wounds

NPWT 125 mmHg showed no clear difference in wound infection compared with standard care (low certainty).

1 finding from 1 review

Negative pressure wound therapy for open traumatic wounds 2018 · Cochrane Headline outcomes only
RR 0.61 [0.31, 1.18]
2 studies · 509 participants
Low