Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

61 questions · 61 findings · 14 reviews · Neuromuscular

No studies found 21 · 34.4%GRADE not reported 2 · 3.3%Very low 18 · 29.5%Low 11 · 18%Moderate 9 · 14.8%High 0 · 0%

Acupuncture plus gastrokinetic agents vs gastrokinetic agents

Proportion of people whose symptoms 'improved' (long term: more than 12 weeks) · symptomatic gastroparesis

It is very uncertain whether acupuncture plus gastrokinetic agents changes proportion of people whose symptoms 'improved' (long term: more than… compared with gastrokinetic agents alone (very low certainty).

1 finding from 1 review

Acupuncture vs sham

Proportion of people whose symptoms 'improved' (long term: more than 12 weeks) ‐ not measured · symptomatic gastroparesis

The review found no eligible studies for this question.

1 finding from 1 review

Methotrexate vs placebo

Participants able to reduce corticosteroid or IVIg dose by more than 20% · people with CIDP

Methotrexate showed no clear difference in participants able to reduce corticosteroid or IVIg dose by more than… compared with placebo (moderate certainty).

1 finding from 1 review

Corticosteroids vs placebo

Improvement in sensory nerve function at 1 year · people with nerve damage (< 6 months' duration) in leprosy

Corticosteroids showed no clear difference in improvement in sensory nerve function at 1 year Defined as a… compared with placebo (moderate certainty).

1 finding from 1 review

Corticosteroids vs placebo

Adverse events Assessed as: occurrence of one or more major adverse events requiring withdrawal of treatment · people with nerve damage (< 6 months' duration) in leprosy

Corticosteroids showed no clear difference in adverse events Assessed as: occurrence of one or more major adverse… compared with placebo (moderate certainty).

1 finding from 1 review

Nocturnal ventilation vs no ventilation

Mortality at 1 year (or more) · patients with neuromuscular and chest wall disorders and chronic hypoventilation

It is very uncertain whether nocturnal ventilation changes mortality at 1 year (or more) compared with no ventilation (very low certainty).

1 finding from 1 review

Volume‐cycled ventilation vs pressure‐cycled ventilation

Mortality at 1 year (or more) Not measured ‐ data reported for mortality at 3 months · patients with neuromuscular and chest wall disorders and chronic hypoventilation

It is very uncertain whether volume‐cycled ventilation changes mortality at 1 year (or more) Not measured ‐ data reported for… compared with pressure‐cycled ventilation (very low certainty).

1 finding from 1 review

IVIg vs PE

Number improved by 1 or more disability grades after 4 weeks · patients with Guillain‐Barré syndrome

IVIg showed no clear difference in number improved by 1 or more disability grades after 4 weeks compared with PE (moderate certainty).

1 finding from 1 review