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What do systematic reviews say?

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Evidence found and GRADE certainty

207 questions · 223 findings · 29 reviews · Headline outcomes only

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No studies found 43 · 19.3%GRADE not reported 14 · 6.3%Very low 39 · 17.5%Low 67 · 30%Moderate 54 · 24.2%High 6 · 2.7%

Methotrexate vs placebo

Health‐related quality of life ‐ not reported · psoriatic arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Methotrexate vs placebo

Change in radiographic progression ‐ not measured · psoriatic arthritis

The review found no eligible studies for this question.

1 finding from 1 review

Methotrexate vs placebo

SAEs · psoriatic arthritis

Methotrexate showed no clear difference in serious adverse events (SAEs) assessed by number of events compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs placebo

Withdrawals due to adverse events · psoriatic arthritis

Methotrexate showed no clear difference in withdrawals due to adverse events (WAEs) assessed by number of events compared with placebo (low certainty).

1 finding from 1 review

Methotrexate vs other DMARDs

Disease response (leflunomide) · psoriatic arthritis

It is very uncertain whether methotrexate changes disease response (leflunomide) compared with other DMARDs (very low certainty).

1 finding from 1 review

Methotrexate vs placebo

Failure to enter remission or possible remission at 16 weeks (Arora 1999) · adult patients with refractory Crohn's disease

Methotrexate showed no clear difference in failure to enter remission or possible remission at 16 weeks (Arora… compared with placebo (low certainty).

3 findings from 1 review

Methotrexate vs 6‐MP or azathioprine

Withdrawals due to adverse events · adult patients with refractory Crohn's disease

It is very uncertain whether methotrexate changes withdrawal due to adverse event (Oren 1997) compared with 6‐MP or azathioprine (very low certainty).

3 findings from 1 review

Methotrexate vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Failure to enter remission or possible remission at 16 weeks (Arora 1999) · adult patients with refractory Crohn's disease

It is very uncertain whether methotrexate changes failure to enter remission or possible remission at 30 weeks… compared with 5‐ASA (very low certainty).

1 finding from 1 review