Parotid hypertrophy prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Parotid hypertrophy was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).
1 finding from 1 review
OR 0.01 [0.00, 0.05]
Studies not reported
Very low
Dental development and maturation · Children and adolescents (<18 years) living with HIV (CLWH)
A single small study suggested delayed dental development in CLWH on ART, but the evidence was insufficient to draw conclusions (very low certainty).
1 finding from 1 review
Oral hygiene · Children and adolescents (<18 years) living with HIV (CLWH)
Oral hygiene status did not differ significantly between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 0.73 [0.13, 4.26]
0 studies
GRADE not reported
Additional physical symptoms · People aged 12 years and over with painful TMD lasting 3 months or longer
The review found no eligible studies for this question.
1 finding from 1 review
Disability caused by pain at follow-up · People aged 12 years and over with painful TMD lasting 3 months or longer
Cognitive behavioural therapy (CBT) showed no clear difference in disability caused by pain at treatment completion compared with alternative (active) treatment (e.g. oral splint, medication,… (low certainty).
2 findings from 1 review
Mucocele prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in mucocele between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 0.02 [0.00, 1.09]
Studies not reported
Very low
Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
cART was associated with a significantly lower prevalence of oral candidiasis in CLWH (very low certainty).
1 finding from 1 review
OR 0.35 [0.24, 0.51]
Studies not reported
Very low
Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Oral candidiasis prevalence did not differ significantly between treatment-naive CLWH and those on monotherapy or dual therapy (very low certainty).
1 finding from 1 review
Angular cheilitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in angular cheilitis between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 0.58 [0.17, 1.99]
Studies not reported
Very low
Ulcerative stomatitis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Ulcerative stomatitis was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).
1 finding from 1 review
OR 0.03 [0.02, 0.07]
Studies not reported
Very low
Periodontal disease prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
ART was not associated with a significant difference in periodontal disease prevalence among CLWH (very low certainty).
1 finding from 1 review
Kaposi's sarcoma prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
Kaposi's sarcoma was significantly more prevalent in treatment-naive CLWH than in those on ART (very low certainty).
1 finding from 1 review
OR 0.00 [0.00, 0.03]
Studies not reported
Very low
Oral candidiasis prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
ART was associated with lower oral candidiasis prevalence.
1 finding from 1 review
OR 0.35 [0.19, 0.63]
7 studies
Very low
Recurrent oral ulceration prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in recurrent oral ulceration between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 1.50 [0.72, 3.13]
Studies not reported
Very low
Oral hairy leukoplakia prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in oral hairy leukoplakia between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 2.75 [0.39, 19.43]
Studies not reported
Very low
Mucosal hyperpigmentation prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in mucosal hyperpigmentation between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 1.79 [0.89, 3.61]
Studies not reported
Very low
Chronic herpes simplex infection prevalence · Children and adolescents (<18 years) living with HIV (CLWH)
No significant difference in chronic herpes simplex infection between CLWH with and without ART (very low certainty).
1 finding from 1 review
OR 2.47 [0.88, 6.97]
Studies not reported
Very low
Adverse events · People aged 12 years and over with painful TMD lasting 3 months or longer
1 finding from 1 review
Caries experience · Children and adolescents (<18 years) living with HIV (CLWH)
ART was not associated with a significant difference in dental caries experience among CLWH (very low certainty).
1 finding from 1 review
Unstimulated whole saliva (UWS) · Adults with medication-related dry mouth
Powered toothbrush showed no clear difference in unstimulated whole saliva (UWS) compared with manual toothbrush; GRADE not reported.
1 finding from 1 review
MD -0.07 [-0.74, 0.60]
1 study
GRADE not reported