What do systematic reviews say?

Medical abortion procedures: mid‐level providers vs doctors

It is very uncertain whether medical abortion procedures: mid‐level providers changes failure/incomplete abortion (observational studies) Verifier… compared with doctors (very low certainty).

• Doctors or mid‐level providers for abortion 2015 · Cochrane Headline outcomes only
  RR 1.09 [0.63, 1.88]
  1 study · 1164 participants
  Very low

Medical abortion procedures: mid‐level providers vs doctors

• Doctors or mid‐level providers for abortion 2015 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 1892 participants
  High

Immediate vs delayed postabortion insertion of contraceptive implants

Immediate probably leads to higher rate of initiation of contraceptive implants—following medical… compared with delayed postabortion insertion of contraceptive implants (moderate certainty).

• Immediate versus delayed postabortal insertion of contraceptive implant 2022 · Cochrane Headline outcomes only
  RR 1.26 [1.21, 1.32]
  2 studies · 1014 participants
  Moderate

Immediate vs delayed postabortion insertion of contraceptive implants

Immediate showed no clear difference in failure rate of medical abortion—overall failure rate at compared with delayed postabortion insertion of contraceptive implants (moderate certainty).

• Immediate versus delayed postabortal insertion of contraceptive implant 2022 · Cochrane Headline outcomes only
  RR 1.18 [0.58, 2.4]
  2 studies · 1001 participants
  Moderate

Immediate vs delayed postabortion insertion of contraceptive implants

Immediate showed no clear difference in failure rate of medical abortion—require extra medication for… compared with delayed postabortion insertion of contraceptive implants (low certainty).

• Immediate versus delayed postabortal insertion of contraceptive implant 2022 · Cochrane Headline outcomes only
  RR 1.18 [0.44, 3.2]
  2 studies · 1001 participants
  Low

Immediate vs delayed postabortion insertion of contraceptive implants

Immediate showed no clear difference in failure rate of medical abortion—require surgery for complete… compared with delayed postabortion insertion of contraceptive implants (moderate certainty).

• Immediate versus delayed postabortal insertion of contraceptive implant 2022 · Cochrane Headline outcomes only
  RR 1.28 [0.71, 2.3]
  2 studies · 1001 participants
  Moderate

Intervention not reported

• Hormonal and intrauterine methods for contraception for women aged 25 years and younger 2015 · Cochrane Headline outcomes only
  no estimate extracted
  193 participants
  Very low

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 228 participants
  Low

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

Summary of findings table ‐ Therapeutic ibuprofen 800 mg showed no clear difference in gastrointestinal side effects (nausea and/or vomiting) compared with prophylactic ibuprofen 800 mg women having medical abortion before… (low certainty).

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  OR 1.67 [0.99, 2.83]
  1 study · 228 participants
  Low

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

The review found no eligible studies for this question.

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

Summary of findings table ‐ Therapeutic ibuprofen 800 mg showed no clear difference in complete abortion rate compared with prophylactic ibuprofen 800 mg women having medical abortion before… (low certainty).

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  OR 1.42 [0.31, 6.5]
  1 study · 228 participants
  Low

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

The review found no eligible studies for this question.

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

Summary of findings table ‐ Therapeutic ibuprofen 800 mg showed no clear difference in unscheduled contact with care compared with prophylactic ibuprofen 800 mg women having medical abortion before… (low certainty).

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  OR 1.03 [0.6, 1.77]
  1 study · 228 participants
  Low

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

The review found no eligible studies for this question.

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Summary of findings table ‐ Ibuprofen 800 mg vs prophylactic ibuprofen 800 mg women having medical abortion before 14 weeks? gestation

Summary of findings table ‐ Therapeutic ibuprofen 800 mg showed no clear difference in patient satisfaction with abortion care overall compared with prophylactic ibuprofen 800 mg women having medical abortion before… (low certainty).

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  OR 0.52 [0.09, 2.89]
  1 study · 228 participants
  Low

Summary of findings table ‐ Ibuprofen 1600 mg vs paracetamol

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 108 participants
  Moderate

Pregabalin 300 mg vs placebo

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 107 participants
  Low

Pregabalin 300 mg vs placebo

Summary of findings table ‐ Pregabalin 300 mg showed no clear difference in gastrointestinal side effects (nausea) compared with placebo (low certainty).

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  OR 0.85 [0.33, 2.19]
  1 study · 107 participants
  Low

Pregabalin 300 mg vs placebo

Summary of findings table ‐ Pregabalin 300 mg showed no clear difference in gastrointestinal side effects (vomiting) compared with placebo (low certainty).

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  OR 0.76 [0.35, 1.63]
  1 study · 107 participants
  Low

Pregabalin 300 mg vs placebo

Summary of findings table ‐ Pregabalin 300 mg showed no clear difference in gastrointestinal side effects (diarrhoea) compared with placebo (low certainty).

• Pain management for medical abortion before 14 weeks’ gestation 2022 · Cochrane Headline outcomes only
  OR 0.82 [0.38, 1.76]
  1 study · 107 participants
  Low