Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
3Mix (ciprofloxacin + metronidazole + minocycline) may leads to higher clinical failure compared with 3Mixtatin (low certainty).
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Treatment failure (annual failure rate) · Children with previously unrestored, vital carious lesions in primary teeth (no pulp therapy); aged 1.5-11 years
Metal-reinforced GIC had a high annual failure rate (29.9%) in a single RCT; low quality of evidence (ungraded).
1 finding from 1 review
Treatment failure (annual failure rate) · Children (aged 3-8 years) with 2-surface occluso-proximal dentine caries in primary molars, no pulp therapy
Preformed metal (Hall) crowns had a low reported annual failure rate (3.1%) versus compomer (14.7%) in one RCT; low quality of evidence (ungraded).
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
3Mix (ciprofloxacin + metronidazole + minocycline) pulpotomy showed no clear difference in clinical failure compared with 3Mix pulpectomy; GRADE not reported.
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
3Mix (ciprofloxacin + metronidazole + minocycline) pulpotomy showed no clear difference in radiological failure compared with 3Mix pulpectomy; GRADE not reported.
1 finding from 1 review
Restoration failure · Children with carious primary teeth after vital or non-vital pulp therapy
In one RCT, composite strip crowns with composite posts had an annual failure rate of 2.3% after 1 year.
1 finding from 1 review
Clinical success (absence of periapical pathology, tenderness to pressure and fistula formation) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
Hodosh 2003 (Analysis 3.1): all 18 patients receiving KNO3/DMI/PCa responded favourably (0/18 developed clinical symptoms) versus 9/17 in the KNO3/PCa group; symptomatic teeth required endodontic therapy or extraction.…
1 study · 35 participants
GRADE not reported
Clinical success (absence of periapical pathology, tenderness to pressure and fistula formation) at 24 months · Adults with asymptomatic teeth with vital carious pulp exposures
1 finding from 1 review
Hodosh 2003 (Analysis 3.1): all 18 patients receiving KNO3/DMI/PCa responded favourably (0/18 developed clinical symptoms) versus 10/12 in the PCa group. "The results in groups two and three were statistically…
1 study · 30 participants
GRADE not reported
Pulp necrosis · Vital teeth
The pooled incidence with ceramic restorations was 5.59%.
1 finding from 1 review
Treatment failure (annual failure rate) · Children with severely decayed maxillary primary incisors treated by pulpectomy (non-vital pulp therapy)
Composite strip crowns with composite posts had a low annual failure rate (2.3%) in maxillary primary incisors after pulpectomy (single high-risk-of-bias RCT; low quality of evidence; not GRADE-rated).
3 findings from 1 review
AFR 2.3
1 study · 54 participants
GRADE not reported
AFR 2.2
1 study · 54 participants
GRADE not reported
AFR 0
1 study · 54 participants
GRADE not reported
Treatment failure (annual failure rate) · Children with previously unrestored, vital carious lesions in primary teeth (no pulp therapy); aged 1.5-11 years
Conventional GIC had an annual failure rate of 7.6-16.6% (2 RCTs) and failed more than amalgam in one trial; low quality of evidence (ungraded).
1 finding from 1 review
Restoration failure · Children with carious primary teeth
No comparative effect estimate was reported; metal-reinforced GIC had the highest failure rate.
1 finding from 1 review
Treatment failure (annual failure rate) · Children with carious primary molars treated by pulpotomy (vital pulp therapy)
Preformed metal crowns had a low annual failure rate (2.4%) in primary molars after pulpotomy, lower than amalgam in the same trial (single high-risk-of-bias RCT; low quality of evidence; not GRADE-rated).
2 findings from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
Mineral trioxide aggregate (MTA) may leads to lower clinical failure compared with 3Mix (ciprofloxacin + metronidazole + minocycline) (low certainty).
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Vitapex (calcium hydroxide/iodoform) showed no clear difference in radiological failure compared with 3Mix (ciprofloxacin + metronidazole + minocycline); GRADE not reported.
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
Vitapex (calcium hydroxide/iodoform) showed no clear difference in clinical failure compared with 3Mix (ciprofloxacin + metronidazole + minocycline); GRADE not reported.
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
1 finding from 1 review
Clinical failure (post dislodgement) · Participants with endodontically-treated permanent premolars restored with a carbon-fibre post (Category III)
Direct composite restoration (final restoration) showed no clear difference in clinical failure (post dislodgement) compared with full-coverage metal-ceramic crown; GRADE not reported.
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Permanent teeth with carious pulp exposure
In partial pulpotomy, MTA had significantly higher success than calcium hydroxide (OR 2.81; ungraded).
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