Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

386 questions · 393 findings · 29 reviews · Airways

No studies found 37 · 9.4%GRADE not reported 40 · 10.2%Very low 30 · 7.6%Low 90 · 22.9%Moderate 149 · 37.9%High 47 · 12%

Beclometasone/LABA vs LABA

Pneumonia · participants with stable stage 3 COPD, smokers and ex‐smokers with a minimum pack‐year history of 20

Beclometasone/LABA showed no clear difference in pneumonia: participants with at least one (dichotomous Peto odds… compared with LABA (low certainty).

1 finding from 1 review

Beclometasone/LABA vs LABA

Exacerbations · participants with stable stage 3 COPD, smokers and ex‐smokers with a minimum pack‐year history of 20

Beclometasone/LABA showed no clear difference in exacerbations: participants with at least one (dichotomous) compared with LABA (moderate certainty).

1 finding from 1 review

Beclometasone/LABA vs LABA

Withdrawal (all‐cause) · participants with stable stage 3 COPD, smokers and ex‐smokers with a minimum pack‐year history of 20

Beclometasone/LABA showed no clear difference in withdrawal (all‐cause) compared with LABA (moderate certainty).

1 finding from 1 review

Regular salmeterol vs salbutamol

All‐cause non‐fatal serious adverse events ‐ adults and adolescents · patients with chronic asthma

Regular salmeterol showed no clear difference in all‐cause non‐fatal serious adverse events ‐ adults and adolescents compared with regular salbutamol (moderate certainty).

1 finding from 1 review

Regular salmeterol vs salbutamol

Asthma‐related non‐fatal serious adverse events ‐ adults and adolescents · patients with chronic asthma

Regular salmeterol showed no clear difference in asthma‐related non‐fatal serious adverse events ‐ adults and… compared with regular salbutamol (low certainty).

1 finding from 1 review

Effects of different delivery devices on growth in children with persistent asthma: hydrofluoroalkane‐metered dose inhaler beclomethasone vs beclomethasone

Linear growth velocity (cm/year) · children up to 18 years of age with persistent asthma

Effects of different delivery devices on growth in children with… showed no clear difference in linear growth velocity (cm/year) compared with chlorofluorocarbon‐metered dose inhaler beclomethasone (low certainty).

1 finding from 1 review