Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,191 questions · 2,354 findings · 362 reviews

No studies found 323 · 13.7%GRADE not reported 382 · 16.2%Very low 555 · 23.6%Low 597 · 25.4%Moderate 345 · 14.7%High 152 · 6.5%

Extraction of lower deciduous canines vs No active treatment (control)

Lower incisor inclination (lingual tipping and retrusion) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Extraction of lower deciduous canines showed no clear difference in lower incisors to mandible (inclination, degrees) at 1 year compared with no active treatment (control); GRADE not reported.

1 finding from 1 review

Extraction of lower deciduous canines vs No active treatment (control)

Amount of crowding · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

It is very uncertain whether extraction of lower deciduous canines changes amount of crowding (lower incisor crowding, change) at 1-2 years compared with no active treatment (control) (very low certainty).

1 finding from 1 review

Extraction of lower deciduous canines vs No active treatment (control)

Size of the lower jaw (arch length, change) · Children or adolescents (aged 16 years old or under) receiving orthodontic treatment to prevent or correct crowded teeth

Extraction of lower deciduous canines led to lower size of the lower jaw (arch length, change) at 1 year compared with no active treatment (control); GRADE not reported.

1 finding from 1 review

Treatment of eclampsia: lower‐dose regimens vs standard‐dose strategies

Death of the baby before discharge: perinatal death · women with eclampsia

It is very uncertain whether treatment of eclampsia: lower‐dose regimens changes death of the baby before discharge: perinatal death: lower dose… compared with standard‐dose regimens (very low certainty).

1 finding from 1 review

Treatment of eclampsia: lower‐dose regimens vs standard‐dose strategies

Recurrence of convulsions · women with eclampsia

It is very uncertain whether treatment of eclampsia: lower‐dose regimens changes recurrence of convulsions: lower dose versus Pritchard regimen compared with standard‐dose regimens (very low certainty).

1 finding from 1 review

Treatment of eclampsia: lower‐dose regimens vs standard‐dose strategies

Severe morbidity (renal failure): lower dose versus Pritchard regimen · women with eclampsia

It is very uncertain whether treatment of eclampsia: lower‐dose regimens changes severe morbidity (renal failure): lower dose versus Pritchard regimen compared with standard‐dose regimens (very low certainty).

1 finding from 1 review

Upper clear plastic retainer + lower fixed canine-to-canine retainer vs Positioner

Stability: Little's Irregularity Index (lower arch) · People who had received fixed appliance orthodontic treatment

Upper clear plastic retainer + lower fixed canine-to-canine retainer led to lower stability: Little's Irregularity Index (lower arch) compared with positioner; GRADE not reported.

1 finding from 1 review

Upper clear plastic retainer + lower interproximal reduction (adjunctive) vs Positioner

Stability: Little's Irregularity Index (lower arch) · People who had received fixed appliance orthodontic treatment

Upper clear plastic retainer + lower interproximal reduction… led to lower stability: Little's Irregularity Index (lower arch) compared with positioner; GRADE not reported.

1 finding from 1 review

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Myocardial infarction · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (high dose) showed no clear difference in myocardial infarction compared with homocysteine‐lowering interventions (low dose) (moderate certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Stroke · people with or without existing cardiovascular disease, men and women

It is very uncertain whether homocysteine‐lowering interventions (high dose) changes stroke compared with homocysteine‐lowering interventions (low dose) (very low certainty).

1 finding from 1 review

Homocysteine‐lowering interventions (high dose) vs homocysteine‐lowering interventions (low dose)

Death by any cause · people with or without existing cardiovascular disease, men and women

Homocysteine‐lowering interventions (high dose) showed no clear difference in death by any cause compared with homocysteine‐lowering interventions (low dose) (moderate certainty).

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery vs later commencement

Wound infection · lower gastrointestinal surgery

It is very uncertain whether early enteral nutrition within 24 hours of lower gastrointestinal… changes wound infection compared with later commencement (very low certainty).

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery vs later commencement

Intraabdominal abscess · lower gastrointestinal surgery

Early enteral nutrition within 24 hours of lower gastrointestinal… showed no clear difference in intraabdominal abscess compared with later commencement (low certainty).

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery vs later commencement

Anastomotic leakage/dehiscence · lower gastrointestinal surgery

Early enteral nutrition within 24 hours of lower gastrointestinal… showed no clear difference in anastomotic leakage/dehiscence compared with later commencement (low certainty).

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery vs later commencement

Pneumonia · lower gastrointestinal surgery

Early enteral nutrition within 24 hours of lower gastrointestinal… showed no clear difference in pneumonia (within hospital stay) compared with later commencement (low certainty).

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery vs later commencement

All‐cause mortality · lower gastrointestinal surgery

Early enteral nutrition within 24 hours of lower gastrointestinal… showed no clear difference in mortality compared with later commencement (low certainty).

1 finding from 1 review