Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

148 questions · 150 findings · 29 reviews · Pain, Palliative and Supportive Care

No studies found 22 · 14.7%GRADE not reported 19 · 12.7%Very low 68 · 45.3%Low 24 · 16%Moderate 13 · 8.7%High 4 · 2.7%

Intervention not reported

Pain: 50% reduction in headache frequency Post‐treatment Lower scores = fewer headaches · Children and adolescents with chronic pain

It is very uncertain whether the intervention changes pain: 50% reduction in headache frequency Post‐treatment Lower… (very low certainty).

1 finding from 1 review

Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Self‐reported health‐related quality of life (0‐100 scale) Higher scores indicate higher burden of disease (lower quality of life) · patients with fibromyalgia

Serotonin noradrenaline reuptake inhibitors showed no clear difference in self‐reported health‐related quality of life (0‐100 scale) Higher… compared with placebo (low certainty).

1 finding from 1 review