Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

375 questions · 390 findings · 22 reviews · Pain, Palliative and Supportive Care

No studies found 117 · 30%GRADE not reported 36 · 9.2%Very low 111 · 28.5%Low 75 · 19.2%Moderate 48 · 12.3%High 3 · 0.8%

Summary of findings: serious adverse events (HEC) when vs treatment with aprepitant + granisetron

Interventions (corticosteroids included in all regimens)a · adult cancer patients at risk for CINV caused by highly emetogenic chemotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings: complete control of vomiting during the overall phase (MEC) when vs treatment with granisetron

Interventions (corticosteroids included in all regimens)a · adult cancer patients at risk for CINV caused by moderately emetogenic chemotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings: serious adverse events (MEC) when vs treatment with granisetron

Interventions (corticosteroids included in all regimens)a · adult cancer patients at risk for CINV caused by moderately emetogenic chemotherapy

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Kappa‐opioid agonists vs placebo

Risk for at least one adverse drug reaction (ADR) per participant · patients with chronic kidney disease (CKD) pruritus

Summary of findings table ‐ Kappa‐opioid agonists may leads to higher risk for at least one adverse drug reaction (ADR) per patient compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table ‐ Ondansetron vs placebo

Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus

It is very uncertain whether summary of findings table ‐ Ondansetron changes risk for at least one adverse event per patient compared with placebo (very low certainty).

1 finding from 1 review

Summary of findings table ‐ Topical capsaicin vs placebo

Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus

Summary of findings table ‐ Topical capsaicin may leads to higher risk for at least one adverse event per patient compared with placebo (low certainty).

1 finding from 1 review

Summary of findings table ‐ Rifampin/rifampicin vs placebo

Risk for at least one adverse event per patient · participants with cholestatic pruritus (CP)

It is very uncertain whether summary of findings table ‐ Rifampin/rifampicin changes risk for at least one adverse event per patient compared with placebo (very low certainty).

1 finding from 1 review

Active stimulation vs Placebo (sham/placebo device)

Adverse events: need for reoperation/ reimplantation · adults with chronic pain

The review found no eligible studies for this question.

3 findings from 1 review

Active stimulation + other intervention vs other intervention alone

Adverse events: need for reoperation/ reimplantation · adults with chronic pain

The review found no eligible studies for this question.

2 findings from 1 review

Intervention not reported

Intervention Total studies: 9 Total participants: 883 · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin, IPC – not daily drainage, doxycycline, placebo Comparator…

The intervention led to lower intervention Total studies: 9 Total participants: 883; GRADE not reported.

1 finding from 1 review