Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

170 questions · 176 findings · 19 reviews · Heart

No studies found 25 · 14.2%GRADE not reported 14 · 8%Very low 32 · 18.2%Low 59 · 33.5%Moderate 34 · 19.3%High 12 · 6.8%

Beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) vs beta‐lactam (ceftriaxone)

Need for cardiac surgical interventions · people with infective endocarditis due to penicillin‐susceptible Streptococci

It is very uncertain whether beta‐lactam (ceftriaxone) plus aminoglycoside (gentamicin) changes need for cardiac surgical interventions compared with beta‐lactam (ceftriaxone) (very low certainty).

1 finding from 1 review

Fosfomycin plus imipenem vs vancomycin

Need for cardiac surgical interventions · people with infective endocarditis due to methicillin‐resistant Staphylococcus aureus

It is very uncertain whether fosfomycin plus imipenem changes need for cardiac surgical interventions compared with vancomycin (very low certainty).

1 finding from 1 review

Face‐to‐face interventions vs control

Physical activity · patients with promoting physical activity

Face‐to‐face interventions showed no clear difference in dichotomous outcomes: 12 months Self‐reported PA questionnaire compared with control (high certainty).

4 findings from 1 review
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