What do systematic reviews say?

Medication given before LTP vs the same medication given after LTP

Medication given before LTP showed no clear difference in IOP increase of ≥ 5 mmHg between 2 and 24 hours compared with the same medication given after LTP (moderate certainty).

• Perioperative medications for preventing temporarily increased intraocular pressure after laser trabeculoplasty 2017 · Cochrane Headline outcomes only
  RR 0.82 [0.25, 2.63]
  4 studies · 319 participants
  Moderate

Medication given before LTP vs the same medication given after LTP

It is very uncertain whether medication given before LTP changes IOP increase of ≥ 10 mmHg between 2 and 24 hours compared with the same medication given after LTP (very low certainty).

• Perioperative medications for preventing temporarily increased intraocular pressure after laser trabeculoplasty 2017 · Cochrane Headline outcomes only
  RR 1.55 [0.19, 12.43]
  4 studies · 319 participants
  Very low

Medication given before LTP vs the same medication given after LTP

• Perioperative medications for preventing temporarily increased intraocular pressure after laser trabeculoplasty 2017 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 198 participants
  Moderate

Medication given before LTP vs the same medication given after LTP

The review found no eligible studies for this question.

• Perioperative medications for preventing temporarily increased intraocular pressure after laser trabeculoplasty 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Medication vs placebo

• Perioperative medications for preventing temporarily increased intraocular pressure after laser trabeculoplasty 2017 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 151 participants
  Moderate

Medication vs placebo

Medication may leads to lower IOP increase of ≥ 5 mmHg between 2 and 24 hours compared with placebo (low certainty).

• Perioperative medications for preventing temporarily increased intraocular pressure after laser trabeculoplasty 2017 · Cochrane Headline outcomes only
  RR 0.17 [0.09, 0.31]
  5 studies · 634 participants
  Low

Medication vs placebo

It is very uncertain whether medication changes IOP increase of ≥ 10 mmHg between 2 and 24 hours compared with placebo (very low certainty).

• Perioperative medications for preventing temporarily increased intraocular pressure after laser trabeculoplasty 2017 · Cochrane Headline outcomes only
  RR 0.22 [0.11, 0.42]
  9 studies · 817 participants
  Very low

Medication vs placebo

• Perioperative medications for preventing temporarily increased intraocular pressure after laser trabeculoplasty 2017 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 151 participants
  Moderate

Medication vs placebo

• Perioperative medications for preventing temporarily increased intraocular pressure after laser trabeculoplasty 2017 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 319 participants
  Moderate

Brimonidine vs apraclonidine

It is very uncertain whether brimonidine changes IOP increase of ≥ 5 mmHg within 2 hours compared with apraclonidine (very low certainty).

• Perioperative medications for preventing temporarily increased intraocular pressure after laser trabeculoplasty 2017 · Cochrane Headline outcomes only
  RR 2.28 [0.32, 16.03]
  2 studies · 71 participants
  Very low

Brimonidine vs apraclonidine

The review found no eligible studies for this question.

• Perioperative medications for preventing temporarily increased intraocular pressure after laser trabeculoplasty 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found