Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

40 questions · 42 findings · 15 reviews · Vascular

No studies found 8 · 19%GRADE not reported 9 · 21.4%Very low 6 · 14.3%Low 12 · 28.6%Moderate 5 · 11.9%High 2 · 4.8%

DOAC vs placebo

Minor bleeding · people requiring prevention of venous thromboembolism following total hip or knee replacement or hip fracture repair

DOAC showed no clear difference in bleeding ‐ minor Treatment duration 28 ‐ 42 days compared with placebo (moderate certainty).

1 finding from 1 review

Vitamin K antagonists vs heparin

Minor bleeding · people requiring prevention of venous thromboembolism following total hip or knee replacement or hip fracture repair

Vitamin K antagonists showed no clear difference in bleeding ‐ minor Treatment duration 28 ‐ 42 days compared with heparin (low certainty).

1 finding from 1 review

DOAC vs heparin

Minor bleeding · people requiring prevention of venous thromboembolism following total hip or knee replacement or hip fracture repair

DOAC showed no clear difference in bleeding ‐ minor Treatment duration 28 ‐ 42 days compared with heparin (high certainty).

1 finding from 1 review

Heparin vs placebo

Minor bleeding · people requiring prevention of venous thromboembolism following total hip or knee replacement or hip fracture repair

Heparin leads to higher bleeding ‐ minor Treatment duration 28 ‐ 42 days compared with placebo (high certainty).

1 finding from 1 review

Knee length vs compression stockings

Deep vein thrombosis · patients with prevention of deep vein thrombosis1

It is very uncertain whether knee length changes deep vein thrombosis (Fixed‐effect analysis) Venous duplex scan,… compared with thigh length graduated compression stockings (very low certainty).

3 findings from 1 review

PGE1 vs inositol niacinate

Adverse events (participants) · people with critical limb ischaemia

PGE1 showed no clear difference in adverse events (participants) compared with inositol niacinate (low certainty).

1 finding from 1 review

PGE1 vs inositol niacinate

Rest‐pain relief · people with critical limb ischaemia

PGE1 showed no clear difference in rest‐pain relief compared with inositol niacinate (low certainty).

1 finding from 1 review

PGE1 vs inositol niacinate

Ulcer healing · people with critical limb ischaemia

PGE1 showed no clear difference in ulcer healing compared with inositol niacinate (low certainty).

1 finding from 1 review