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Evidence found and GRADE certainty

27 questions · 27 findings · 6 reviews · Haematology

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No studies found 4 · 14.8%GRADE not reported 4 · 14.8%Very low 14 · 51.9%Low 0 · 0%Moderate 5 · 18.5%High 0 · 0%

ATRA in addition to chemotherapy vs chemotherapy alone

Mortality, relapse and progresses (instead of disease‐ or relapse‐free survival) · adults with acute myeloid leukaemia (AML) (non‐acute promyelocytic leukaemia (APL))

ATRA in addition to chemotherapy showed no clear difference in mortality, relapse and progresses (instead of disease‐ or… compared with chemotherapy only (moderate certainty).

1 finding from 1 review

ATRA in addition to chemotherapy vs chemotherapy alone

On‐study mortality · adults with acute myeloid leukaemia (AML) (non‐acute promyelocytic leukaemia (APL))

ATRA in addition to chemotherapy showed no clear difference in on‐study mortality compared with chemotherapy only (moderate certainty).

1 finding from 1 review

ATRA in addition to chemotherapy vs chemotherapy alone

Severe adverse effects (grade 3+): Infection · adults with acute myeloid leukaemia (AML) (non‐acute promyelocytic leukaemia (APL))

ATRA in addition to chemotherapy showed no clear difference in infection grade III/IV compared with chemotherapy only (moderate certainty).

1 finding from 1 review

ATRA in addition to chemotherapy vs chemotherapy alone

Grade 3 to 4 diarrhoea · adults with acute myeloid leukaemia (AML) (non‐acute promyelocytic leukaemia (APL))

It is very uncertain whether ATRA in addition to chemotherapy changes diarrhoea grade III/IV compared with chemotherapy only (very low certainty).

1 finding from 1 review

ATRA in addition to chemotherapy vs chemotherapy alone

Toxicity: grade 3 or 4 nausea ± vomiting · adults with acute myeloid leukaemia (AML) (non‐acute promyelocytic leukaemia (APL))

It is very uncertain whether ATRA in addition to chemotherapy changes nausea/vomiting grade III/IV compared with chemotherapy only (very low certainty).

1 finding from 1 review

ATRA in addition to chemotherapy vs chemotherapy alone

Cardiac toxicity grade III/IV · adults with acute myeloid leukaemia (AML) (non‐acute promyelocytic leukaemia (APL))

It is very uncertain whether ATRA in addition to chemotherapy changes cardiac toxicity grade III/IV compared with chemotherapy only (very low certainty).

1 finding from 1 review