Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

89 questions · 89 findings · 18 reviews · Gynaecological, Neuro-oncology and Orphan Cancer

No studies found 11 · 12.4%GRADE not reported 3 · 3.4%Very low 21 · 23.6%Low 26 · 29.2%Moderate 17 · 19.1%High 11 · 12.4%

Summary of findings: Aminosalicylates vs placebo

Acute and late GI toxicity (grade 2+) · People undergoing pelvic radiotherapy for urological, gynaecological or colorectal cancer

Summary of findings: Aminosalicylates probably leads to higher acute and late GI toxicity (grade 2+) compared with placebo (moderate certainty).

1 finding from 1 review

Summary of findings: quinolone prophylaxis vs TMP‐SMZ prophylaxis

All cause‐mortality · cancer patients with afebrile neutropenia following chemotherapy

Summary of findings: quinolone prophylaxis probably leads to higher all cause‐mortality compared with TMP‐SMZ prophylaxis (moderate certainty).

1 finding from 1 review

Summary of findings: quinolone prophylaxis vs TMP‐SMZ prophylaxis

Febrile patients and episodes · cancer patients with afebrile neutropenia following chemotherapy

Summary of findings: quinolone prophylaxis probably leads to lower febrile patients and episodes compared with TMP‐SMZ prophylaxis (moderate certainty).

1 finding from 1 review

Direct oral anticoagulant (DOAC) prophylaxis vs no prophylaxis

Minor bleeding · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

Direct oral anticoagulant (DOAC) prophylaxis showed no clear difference in minor bleeding compared with no prophylaxis (low certainty).

1 finding from 1 review

Vitamin K antagonist (VKA) prophylaxis vs no prophylaxis

Minor bleeding · ambulatory people with cancer without venous thromboembolism receiving systemic therapy

Vitamin K antagonist (VKA) prophylaxis probably leads to higher minor bleeding compared with no prophylaxis (moderate certainty).

1 finding from 1 review

Vitamin K antagonists vs low molecular weight heparin

Minor bleeding · ambulatory patients with multiple myeloma receiving immunomodulatory agents

It is very uncertain whether vitamin K antagonist (VKA) changes minor bleeding compared with low molecular weight heparin (LMWH) (very low certainty).

1 finding from 1 review

Nonavalent HPV vaccine vs quadrivalent HPV vaccine

High‐grade cervical intraepithelial neoplasia, adenocarcinoma in situ, and cervical cancer · 9‐ to 26‐year‐old females and males

Nonavalent HPV vaccine showed no clear difference in high‐grade cervical intraepithelial neoplasia, adenocarcinoma in… compared with quadrivalent HPV vaccine (high certainty).

1 finding from 1 review