Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

45 questions · 46 findings · 6 reviews · Vascular

No studies found 14 · 30.4%GRADE not reported 1 · 2.2%Very low 17 · 37%Low 12 · 26.1%Moderate 2 · 4.3%High 0 · 0%

TNF‐α blockers intervention vs placebo or additional treatment

Adverse effects after treatment initiation: injection site reactions, neutropenia, infections, demyelinating disease, heart failure, malignancy, and induction of autoimmunity. · children diagnosed with Kawasaki disease

The review found no eligible studies for this question.

1 finding from 1 review

Foam sclerotherapy vs placebo

Complications ‐ DVT · participants with varicose veinsa

It is very uncertain whether foam sclerotherapy changes complications ‐ DVT compared with placebo (very low certainty).

1 finding from 1 review

Foam sclerotherapy vs placebo

Residual varicose veins · participants with varicose veinsa

It is very uncertain whether foam sclerotherapy changes residual varicose veins compared with placebo (very low certainty).

1 finding from 1 review