Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

74 questions · 74 findings · 25 reviews · Eyes and Vision

No studies found 13 · 17.6%GRADE not reported 0 · 0%Very low 21 · 28.4%Low 20 · 27%Moderate 20 · 27%High 0 · 0%

Any intervention vs artificial tears or saline

Proportion of participants in whose eyes SEI had disappeared within 21 days of treatment (higher is favored) · epidemic keratoconjunctivitis

It is very uncertain whether any intervention changes proportion of participants in whose eyes SEI had disappeared within… compared with artificial tears or saline (very low certainty).

1 finding from 1 review

Non‐biologic disease‐modifying antirheumatic drugs (DMARDs) vs steroids

Proportion of participants achieving control of inflammation (higher number of events is better) · NIIPPU

It is very uncertain whether non‐biologic disease‐modifying antirheumatic drugs (DMARDs) changes proportion of participants achieving control of inflammation (higher… compared with steroid (very low certainty).

1 finding from 1 review

Methotrexate vs mycophenolate

Proportion of participants achieving steroid‐sparing control (higher number of events is better) · NIIPPU

Methotrexate probably leads to higher proportion of participants achieving steroid‐sparing control§… compared with mycophenolate (moderate certainty).

1 finding from 1 review

Steroids with or without azathioprine vs cyclosporine A

Proportion of participants achieving control of inflammation (higher number of events is better) · NIIPPU

It is very uncertain whether steroids with or without azathioprine changes proportion of participants achieving control of inflammation (higher… compared with cyclosporine A (very low certainty).

1 finding from 1 review

Steroids with or without azathioprine vs cyclosporine A

Proportion of participants achieving steroid‐sparing control (higher number of events is better) · NIIPPU

It is very uncertain whether steroids with or without azathioprine changes proportion of participants achieving steroid‐sparing control (higher… compared with cyclosporine A (very low certainty).

1 finding from 1 review

Non‐biologic disease‐modifying antirheumatic drugs (DMARDs) vs steroids

Proportion of participants achieving a 2‐line improvement in visual acuity (Snellen chart) (higher scores indicate better vision) · NIIPPU

The review found no eligible studies for this question.

1 finding from 1 review

Methotrexate vs mycophenolate

Proportion of participants achieving control of inflammation (higher number of events is better) · NIIPPU

Methotrexate probably leads to higher proportion of participants achieving control of inflammation§… compared with mycophenolate (moderate certainty).

1 finding from 1 review