Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

534 questions · 539 findings · 63 reviews · Pregnancy and Childbirth

No studies found 101 · 18.7%GRADE not reported 63 · 11.7%Very low 93 · 17.3%Low 167 · 31%Moderate 89 · 16.5%High 26 · 4.8%

Dexamethasone: oral vs intramuscular – fetal/neonatal outcomes

Any known death after randomisation (fetal, neonatal, child, child as adult) · women at risk of preterm birth

It is very uncertain whether dexamethasone: oral changes any known death after randomisation (fetal, neonatal, child, child… compared with intramuscular – fetal/neonatal outcomes (very low certainty).

1 finding from 1 review

Betamethasone acetate plus phosphate vs betamethasone phosphate – fetal/neonatal outcomes

Any known death after randomisation (fetal, neonatal, child, child as adult) · women at risk of preterm birth

It is very uncertain whether betamethasone acetate plus phosphate changes any known death after randomisation (fetal, neonatal, child, child… compared with betamethasone phosphate – fetal/neonatal outcomes (very low certainty).

1 finding from 1 review

Betamethasone 12‐hourly vs 24‐hourly dosing – fetal/neonatal outcomes

Any known death after randomisation (fetal, neonatal, child, child as adult) · women at risk of preterm birth

It is very uncertain whether betamethasone 12‐hourly changes any known death after randomisation (fetal, neonatal, child, child… compared with 24‐hourly dosing – fetal/neonatal outcomes (very low certainty).

1 finding from 1 review

Dexamethasone vs betamethasone – child outcomes

Any known death after randomisation (fetal, neonatal, child, child as adult) · women at risk of preterm birth

Dexamethasone showed no clear difference in any known death after randomisation (fetal, neonatal, child, child… compared with betamethasone – fetal/neonatal outcomes (moderate certainty).

1 finding from 1 review

Summary of findings for selective ß2‐adrenergic agonist vs no tocolytic agent, whilst awaiting emergency delivery

Fetal or neonatal mortality · women with fetal distress for whom the decision had been made to delivery by emergency caesarean section

Summary of findings for selective ß2‐adrenergic agonist showed no clear difference in fetal or neonatal mortality compared with no tocolytic agent, whilst awaiting emergency delivery (low certainty).

1 finding from 1 review

Summary of findings for IV hexoprenaline vs no tocolytic agent, whilst awaiting emergency delivery

Fetal or neonatal mortality · women for whom a decision had been made to deliver by caesarean section for suspected fetal distress based on FHR monitoring

Summary of findings for IV hexoprenaline showed no clear difference in fetal or neonatal mortality compared with no tocolytic agent, whilst awaiting emergency delivery (low certainty).

1 finding from 1 review

Summary of findings for subcutaneous terbutaline vs IV magnesium sulphate

Resolution of fetal distress on FHR tracing · women for whom a decision had been made to deliver by caesarean section for suspected fetal distress based on FHR monitoring

It is very uncertain whether summary of findings for subcutaneous terbutaline changes resolution of fetal distress on FHR tracing compared with IV magnesium sulphate (very low certainty).

1 finding from 1 review

Summary of findings for subcutaneous terbutaline with continuation of oxytocic infusion vs cessation of oxytocic infusion without tocolytic agent

Fetal or neonatal mortality · women who developed uterine hyperstimulation in labour with oxytocin augmentation, but without signs of fetal distress

The review found no eligible studies for this question.

1 finding from 1 review

Routine/revealed vs selective/concealed ultrasound

Detection of fetal abnormality before 24 weeks' gestation · Fetal ultrasound assessment before 24 weeks' gestation

Routine/revealed probably leads to higher detection of fetal abnormality before 24 weeks' gestation compared with selective/concealed ultrasound (moderate certainty).

1 finding from 1 review

Fetal biometry vs maternal glycaemic values

Hypertensive disorders of pregnancy · women with gestational diabetes mellitus and their babies

It is very uncertain whether fetal biometry changes hypertensive disorders of pregnancy (including pre‐eclampsia,… compared with maternal glycaemic values (very low certainty).

1 finding from 1 review

Fetal biometry vs maternal glycaemic values

Large‐for‐gestational age · women with gestational diabetes mellitus and their babies

It is very uncertain whether fetal biometry changes large‐for‐gestational age compared with maternal glycaemic values (very low certainty).

1 finding from 1 review