Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

224 questions · 272 findings · 31 reviews · Dental caries

No studies found 23 · 8.5%GRADE not reported 170 · 62.5%Very low 64 · 23.5%Low 6 · 2.2%Moderate 9 · 3.3%High 0 · 0%

Restorative dental treatment under general anesthesia vs Before treatment (before-after)

Oral health-related quality of life (child and family) · Preschool children in the United Arab Emirates receiving dental general anesthesia

One study found restorative dental treatment under general anesthesia significantly improved oral health-related quality of life for preschool children and their families (narrative synthesis; not GRADE-rated).

1 finding from 1 review

Self-etch adhesive + acetone-based total-etch adhesive vs Acetone-based total-etch adhesive

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether self-etch adhesive + acetone-based total-etch adhesive changes clinical failure compared with acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Self-etch adhesive + acetone-based total-etch adhesive vs Non-rinse conditioner + acetone-based total-etch adhesive

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether self-etch adhesive + acetone-based total-etch adhesive changes radiological failure compared with non-rinse conditioner + acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Self-etch adhesive + acetone-based total-etch adhesive vs Total-etching 36% phosphoric acid + acetone-based total-etch adhesive

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether self-etch adhesive + acetone-based total-etch adhesive changes clinical failure compared with total-etching 36% phosphoric acid + acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Self-etch adhesive + acetone-based total-etch adhesive vs Acetone-based total-etch adhesive

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether self-etch adhesive + acetone-based total-etch adhesive changes radiological failure compared with acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Self-etch adhesive + acetone-based total-etch adhesive vs Non-rinse conditioner + acetone-based total-etch adhesive

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether self-etch adhesive + acetone-based total-etch adhesive changes clinical failure compared with non-rinse conditioner + acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Self-etch adhesive + acetone-based total-etch adhesive vs Total-etching 36% phosphoric acid + acetone-based total-etch adhesive

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether self-etch adhesive + acetone-based total-etch adhesive changes radiological failure compared with total-etching 36% phosphoric acid + acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Composite resin with etch-and-rinse (total-etch) adhesion vs Composite resin with self-etch adhesion (same universal adhesive)

Treatment failure (annual failure rate) · Children with moderately deep dentine caries in primary molars, no pulp therapy

Etch-and-rinse adhesion failed more than self-etch (19.5% vs 7.0% annual failure) in one RCT; low quality of evidence (ungraded).

1 finding from 1 review

Non-rinse conditioner + acetone-based total-etch adhesive vs Acetone-based total-etch adhesive

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether non-rinse conditioner + acetone-based total-etch adhesive changes radiological failure compared with acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Total-etching 36% phosphoric acid + acetone-based total-etch adhesive vs Acetone-based total-etch adhesive

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes radiological failure compared with acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Total-etching 36% phosphoric acid + acetone-based total-etch adhesive vs Non-rinse conditioner + acetone-based total-etch adhesive

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes clinical failure compared with non-rinse conditioner + acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Total-etching 36% phosphoric acid + acetone-based total-etch adhesive vs Acetone-based total-etch adhesive

Clinical failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes clinical failure compared with acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Total-etching 36% phosphoric acid + acetone-based total-etch adhesive vs Non-rinse conditioner + acetone-based total-etch adhesive

Radiological failure · Children with extensive decay involving the dental pulp in primary teeth

It is very uncertain whether total-etching 36% phosphoric acid + acetone-based total-etch adhesive changes radiological failure compared with non-rinse conditioner + acetone-based total-etch adhesive (very low certainty).

1 finding from 1 review

Adhesive precoated (APC) flash-free brackets (minimal excess adhesive) vs Conventional ceramic brackets

Enamel demineralization (DIAGNOdent score) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Adhesive precoated flash-free brackets showed no demineralization difference, with certainty not graded.

1 finding from 1 review

One-step adhesive bonding system (GC Ortho Connect) vs Conventional three-step bonding system (3M Transbond XT)

White spot lesion incidence, area, and depth · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

GC Ortho Connect had more frequent, larger, and deeper WSLs, with certainty not graded.

1 finding from 1 review

Indirect bonding using flowable composite adhesive (Opal Bond MV) vs Direct bonding (conventional, Transbond XT)

White spot lesion formation (QLF: fluorescence loss, lesion area) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Indirect bonding with a flowable adhesive favored less QLF-measured demineralization, with certainty not graded.

1 finding from 1 review

Indirect bonding using flowable composite adhesive (Opal Bond MV) vs Direct bonding (conventional, Transbond XT)

White spot lesion formation (QLF: fluorescence loss, lesion area) · Patients undergoing fixed orthodontic (fixed appliance) treatment (adolescents and adults, ages 12 to 35)

A single RCT found indirect bonding with flowable composite reduced white spot lesion formation versus direct bonding (ungraded).

1 finding from 1 review

Adhesively bonded amalgam restorations in conventional preparations utilising deliberate retention (all bonding agents) vs Amalgam restoration

Marginal deterioration of the restoration and fracture of the remaining tooth tissue · Adults and adolescents with permanent posterior molar and premolar teeth suitable for Class I and II, but excluding Class V, amalgam…
1 finding from 1 review

Adhesively bonded amalgam restorations in conventional preparations utilising deliberate retention (all bonding agents) vs Amalgam restoration

Restoration survival · Adults and adolescents with permanent posterior molar and premolar teeth suitable for Class I and II, but excluding Class V, amalgam…
1 finding from 1 review