Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

69 questions · 74 findings · 9 reviews

No studies found 4 · 5.4%GRADE not reported 26 · 35.1%Very low 8 · 10.8%Low 15 · 20.3%Moderate 20 · 27%High 1 · 1.4%

Summary of findings table ‐ Progestogens vs GnRH antagonists

Clinical pregnancy · assisted reproduction technology cycles

Summary of findings table ‐ Progestogens showed no clear difference in clinical pregnancy ‐ Poor‐responders (MPA 10 mg versus GnRH… compared with gnRH antagonists (low certainty).

1 finding from 1 review

Summary of findings table ‐ Progestogens vs GnRH antagonists

Live birth or ongoing pregnancy ‐ Poor‐responders (MPA 10 mg versus GnRH antagonists) ‐ Own oocytes ‐ Early phase stimulation protocol · assisted reproduction technology cycles

Summary of findings table ‐ Progestogens showed no clear difference in live birth or ongoing pregnancy ‐ Poor‐responders (MPA 10 mg versus… compared with gnRH antagonists; GRADE not reported.

1 finding from 1 review

Gonadotropins with GnRH antagonist vs gonadotropins alone

Live birth rate per couple · intrauterine insemination (IUI) in women with infertility

It is very uncertain whether gonadotropins with GnRH antagonist changes live birth rate per couple compared with gonadotropins alone (very low certainty).

1 finding from 1 review

Gonadotropins with GnRH antagonist vs gonadotropins alone

Multiple pregnancy rate · intrauterine insemination (IUI) in women with infertility

Gonadotropins with GnRH antagonist showed no clear difference in multiple pregnancy rate per couple compared with gonadotropins alone (moderate certainty).

1 finding from 1 review

Gonadotropins with GnRH antagonist vs gonadotropins alone

Clinical pregnancy rate · intrauterine insemination (IUI) in women with infertility

Gonadotropins with GnRH antagonist showed no clear difference in clinical pregnancy rate per couple compared with gonadotropins alone (low certainty).

1 finding from 1 review

Gonadotropins with GnRH antagonist vs gonadotropins alone

Ectopic pregnancy rate per couple · intrauterine insemination (IUI) in women with infertility

Gonadotropins with GnRH antagonist showed no clear difference in ectopic pregnancy rate per couple compared with gonadotropins alone (low certainty).

1 finding from 1 review

GnRH agonist‐antagonist cotreatment plus chemotherapy vs chemotherapy alone

Pregnancy · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

It is very uncertain whether gnRH agonist‐antagonist cotreatment plus chemotherapy changes pregnancy compared with chemotherapy alone (very low certainty).

1 finding from 1 review

GnRH agonist‐antagonist cotreatment plus chemotherapy vs chemotherapy alone

Menstruation recovery or maintenance: · premenopausal women with malignant conditions, receiving GnRH agonist before or in parallel to chemotherapy

It is very uncertain whether gnRH agonist‐antagonist cotreatment plus chemotherapy changes menstruation recovery or maintenance: compared with chemotherapy alone (very low certainty).

2 findings from 1 review