Findings

What do systematic reviews say?

56 questions · 57 findings · 4 reviews

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No studies found 4 · 7%GRADE not reported 7 · 12.3%Very low 22 · 38.6%Low 24 · 42.1%Moderate 0 · 0%High 0 · 0%

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Growth velocity, head circumference, mm/d, end of intervention · parenterally fed preterm infants with cholestasis

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Death of baby (up to discharge) · parenterally fed preterm infants with cholestasis

It is very uncertain whether fish oil lipid emulsion (LE) changes death before discharge – MOFS‐LE vs S‐LE – Pure F‐LE vs IL compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 0.24 [0.03, 1.87]
2 studies · 40 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Any sepsis – MOFS‐LE vs S‐LE – Pure F‐LE vs IL · parenterally fed preterm infants with cholestasis

It is very uncertain whether fish oil lipid emulsion (LE) changes any sepsis – MOFS‐LE vs S‐LE – Pure F‐LE vs IL compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.21 [0.5, 2.92]
2 studies · 40 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Conjugated bilirubin levels · parenterally fed preterm infants with cholestasis

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Death of baby (up to discharge) · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in death before discharge – MOFS‐LE vs S‐LE compared with non‐fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1.24 [0.81, 1.9]
9 studies · 855 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Oxygen requirement at 36 weeks' postmenstrual age · Parenterally fed preterm infants

Fish oil lipid emulsion (LE) showed no clear difference in CLD (oxygen requirement at 36 weeks' postmenstrual age) – MOFS‐LE vs… compared with non‐fish oil LE (low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
RR 1 [0.75, 1.34]
6 studies · 581 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Conjugated bilirubin levels · Parenterally fed preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 673 participants
Low

Intravenous soya oil‐derived (n‐6) fatty acid‐based lipid emulsion vs intravenous fish oil‐derived (n‐3) fatty acid‐based lipid emulsion

Proportion of participants achieving clear or almost clear skin (PASI 90 to 100 or PGA 0 to 1) · guttate psoriasis

The review found no eligible studies for this question.

1 finding from 1 review

Non‐antistreptococcal interventions for acute guttate psoriasis or an acute guttate flare of chronic psoriasis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intravenous soya oil‐derived (n‐6) fatty acid‐based lipid emulsion vs intravenous fish oil‐derived (n‐3) fatty acid‐based lipid emulsion

Percentage of participants with adverse effects and severe adverse effects · guttate psoriasis

The review found no eligible studies for this question.

1 finding from 1 review

Non‐antistreptococcal interventions for acute guttate psoriasis or an acute guttate flare of chronic psoriasis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intravenous soya oil‐derived (n‐6) fatty acid‐based lipid emulsion vs intravenous fish oil‐derived (n‐3) fatty acid‐based lipid emulsion

Number of relapses of guttate psoriasis or flares within a period of 6 months after the treatment has finished · guttate psoriasis

The review found no eligible studies for this question.

1 finding from 1 review

Non‐antistreptococcal interventions for acute guttate psoriasis or an acute guttate flare of chronic psoriasis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intravenous soya oil‐derived (n‐6) fatty acid‐based lipid emulsion vs intravenous fish oil‐derived (n‐3) fatty acid‐based lipid emulsion

Proportion of participants achieving PASI 75 or PGA 1 to 2 · guttate psoriasis

The review found no eligible studies for this question.

1 finding from 1 review

Non‐antistreptococcal interventions for acute guttate psoriasis or an acute guttate flare of chronic psoriasis 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intravenous soya oil‐derived (n‐6) fatty acid‐based lipid emulsion vs intravenous fish oil‐derived (n‐3) fatty acid‐based lipid emulsion

Improvement in participant satisfaction measures and quality of life assessment measures Overall subjective score on 5 items (appearance of lesions, impairment of daily life, pruritus, burning, and pain) reported through figures · guttate psoriasis

1 finding from 1 review

Non‐antistreptococcal interventions for acute guttate psoriasis or an acute guttate flare of chronic psoriasis 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 21 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) – pure F‐LE vs S‐LE · parenterally fed term and late preterm infants with surgical conditions

It is very uncertain whether fish oil LE changes PNALD/cholestasis (conjugated bilirubin ≥ 2 mg/dL) Pure F‐LE vs S‐LE compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes only
RR 1.11 [0.08, 15.28]
1 study · 19 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Resolution of PNALD/cholestasis (conjugated bilirubin less than2 mg/dL) Pure F‐LE vs S‐LE · parenterally fed term and late preterm infants

It is very uncertain whether fish oil LE changes resolution of PNALD/cholestasis (conjugated bilirubin less than2… compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes only
RR 5.6 [0.34, 93.35]
1 study · 16 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Growth · parenterally fed term and late preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Any sepsis (clinical and/or culture positive) · parenterally fed term and late preterm infants

It is very uncertain whether fish oil LE changes any sepsis (clinical or culture positive (or both)) MOFS‐LE vs S‐LE… compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes only
RR 1.21 [0.5, 2.92]
2 studies · 40 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Hypertriglyceridaemia · parenterally fed term and late preterm infants

It is very uncertain whether fish oil LE changes hypertriglyceridaemia compared with non‐fish oil LE (very low certainty).

1 finding from 1 review

Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes only
RR 0.79 [0.3, 2.09]
1 study · 24 participants
Very low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Conjugated bilirubin levels · parenterally fed term and late preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

ALP U/L · parenterally fed term and late preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 24 participants
Low

Fish oil lipid emulsion (LE) vs non‐fish oil LE

Rate of change of conjugated bilirubin · parenterally fed term and late preterm infants

1 finding from 1 review

Lipid emulsions for parenterally fed term and late preterm infants 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 16 participants
Very low