What do systematic reviews say?

Summary of findings table ‐ Early amino acids vs Late amino acids

Summary of findings table ‐ Early amino acids showed no clear difference in neurodevelopmental outcome assessed by any standard tool compared with late amino acids (low certainty).

• Early versus late administration of amino acids in preterm infants receiving parenteral nutrition 2024 · Cochrane Headline outcomes only
  OR 0.83 [0.21, 3.28]
  1 study · 111 participants
  Low

Summary of findings table ‐ Early amino acids vs Late amino acids

• Early versus late administration of amino acids in preterm infants receiving parenteral nutrition 2024 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Summary of findings table ‐ Early amino acids vs Late amino acids

• Early versus late administration of amino acids in preterm infants receiving parenteral nutrition 2024 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 93 participants
  Low

Higher vs lower amino acid intake

Higher showed no clear difference in mortality to hospital discharge compared with lower amino acid intake (low certainty).

• Higher versus lower amino acid intake in parenteral nutrition for newborn infants 2018 · Cochrane Headline outcomes only
  RR 0.9 [0.69, 1.17]
  14 studies · 1407 participants
  Low

Higher vs lower amino acid intake

It is very uncertain whether higher changes neurodevelopmental disability compared with lower amino acid intake (very low certainty).

• Higher versus lower amino acid intake in parenteral nutrition for newborn infants 2018 · Cochrane Headline outcomes only
  RR 1.04 [0.48, 2.23]
  2 studies · 201 participants
  Very low

Higher vs lower amino acid intake

It is very uncertain whether higher changes postnatal growth failure at discharge (weight < 10th centile) compared with lower amino acid intake (very low certainty).

• Higher versus lower amino acid intake in parenteral nutrition for newborn infants 2018 · Cochrane Headline outcomes only
  RR 0.74 [0.56, 0.97]
  3 studies · 203 participants
  Very low

Higher vs lower amino acid intake

• Higher versus lower amino acid intake in parenteral nutrition for newborn infants 2018 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 291 participants
  Very low

Higher vs lower amino acid intake

• Higher versus lower amino acid intake in parenteral nutrition for newborn infants 2018 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 315 participants
  Very low

Higher vs lower amino acid intake

It is very uncertain whether higher changes retinopathy of prematurity compared with lower amino acid intake (very low certainty).

• Higher versus lower amino acid intake in parenteral nutrition for newborn infants 2018 · Cochrane Headline outcomes only
  RR 0.44 [0.21, 0.93]
  4 studies · 269 participants
  Very low

Higher vs lower amino acid intake

Higher leads to higher abnormal blood urea nitrogen (various criteria) compared with lower amino acid intake (high certainty).

• Higher versus lower amino acid intake in parenteral nutrition for newborn infants 2018 · Cochrane Headline outcomes only
  RR 2.77 [2.13, 3.61]
  7 studies · 688 participants
  High