Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

43 questions · 43 findings · 4 reviews · Pregnancy and Childbirth

No studies found 6 · 14%GRADE not reported 2 · 4.7%Very low 24 · 55.8%Low 11 · 25.6%Moderate 0 · 0%High 0 · 0%

Vaginal misoprostol vs placebo

Opiate use (as a proxy measure for pain) for all participants on ITT (including those without confirmed AMI) · early fetal death (less than 24 weeks)

It is very uncertain whether vaginal misoprostol changes pain (opiate use) compared with placebo (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis: UFH vs no treatment

Symptomatic thromboembolic events ( · women with varicose veins before birth, having a caesarean (elective or emergency) or vaginal birth

It is very uncertain whether peripartum/postnatal prophylaxis: UFH changes symptomatic thromboembolic events ( compared with no treatment (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis: UFH vs no treatment

Symptomatic PE · women with varicose veins before birth, having a caesarean (elective or emergency) or vaginal birth

It is very uncertain whether peripartum/postnatal prophylaxis: UFH changes symptomatic PE ( compared with no treatment (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis: UFH vs no treatment

Symptomatic DVT · women with varicose veins before birth, having a caesarean (elective or emergency) or vaginal birth

It is very uncertain whether peripartum/postnatal prophylaxis: UFH changes symptomatic DVT ( compared with no treatment (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) vs no treatment/placebo

Symptomatic thromboembolic events ( · women giving birth by elective or emergency caesarean (elective only (1 trial), emergency or elective (4 trials))

It is very uncertain whether peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) changes symptomatic thromboembolic events (timing of assessment unclear,… compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) vs no treatment/placebo

Symptomatic PE · women giving birth by elective or emergency caesarean (elective only (1 trial), emergency or elective (4 trials))

It is very uncertain whether peripartum/postnatal prophylaxis (caesarean): heparin (LMWH or UFH) changes symptomatic PE (timing of assessment unclear, within 6 weeks… compared with no treatment/placebo (very low certainty).

1 finding from 1 review

Chlorhexidine (vaginal wash or gel/cream) vs placebo or no treatment

GBS pneumonia within the first seven days of life · women with vaginal or rectal colonization with GBS during labour and their preterm/term infants

It is very uncertain whether chlorhexidine (vaginal wash or gel/cream) changes GBS pneumonia within the first seven days of life compared with placebo or no treatment (very low certainty).

1 finding from 1 review