Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

43 questions · 43 findings · 8 reviews · Kidney and Transplant

No studies found 9 · 20.9%GRADE not reported 2 · 4.7%Very low 6 · 14%Low 14 · 32.6%Moderate 8 · 18.6%High 4 · 9.3%

Percutaneous vs open surgical PD catheter insertion

Early PD catheter function (within 4 weeks of PD catheter insertion) · improving catheter function and clinical outcomes in PD patients

It is very uncertain whether percutaneous changes early PD catheter function (within 4 weeks of PD catheter insertion) compared with open surgical PD catheter insertion (very low certainty).

1 finding from 1 review

Peritoneoscopic vs open surgical PD catheter insertion

Early PD catheter function (within 4 weeks of PD catheter insertion) · improving catheter function and clinical outcomes in PD patients

It is very uncertain whether peritoneoscopic changes early PD catheter function (within 4 weeks of PD catheter insertion)… compared with open surgical PD catheter insertion (very low certainty).

1 finding from 1 review

Medical vs open surgical PD catheter insertion

Early PD catheter function (within 4 weeks of PD catheter insertion) · improving catheter function and clinical outcomes in PD patients

Medical showed no clear difference in early PD catheter function (within 4 weeks of PD catheter insertion) compared with open surgical PD catheter insertion (low certainty).

1 finding from 1 review

Antiplatelet agent vs control

Early access thrombosis (before 8 weeks) · people with chronic kidney disease (predialysis (GFR 15 to 60 mL/min/1.73 m²), HD, PD, transplant recipients)

Antiplatelet agents may leads to lower early access thrombosis (before 8 weeks) compared with control (low certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs placebo

CVD events: total (fatal and non‐fatal) · adults with early (stage 1 to 3) non‐diabetic CKD

Angiotensin‐converting enzyme inhibitors showed no clear difference in CVD events: total (fatal and non‐fatal) compared with placebo (low certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs placebo

Number of participants reporting an adverse event · adults with early (stage 1 to 3) non‐diabetic CKD

Angiotensin‐converting enzyme inhibitors may leads to higher adverse events: number reporting an adverse event compared with placebo (low certainty).

1 finding from 1 review

Angiotensin receptor blockers (ARBs) vs placebo

Number of participants reporting an adverse event · adults with early (stage 1 to 3) non‐diabetic CKD

It is very uncertain whether angiotensin receptor blockers changes adverse events (number reporting an adverse event) compared with placebo (very low certainty).

1 finding from 1 review