Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

89 questions · 89 findings · 17 reviews · Headline outcomes only

No studies found 11 · 12.4%GRADE not reported 1 · 1.1%Very low 18 · 20.2%Low 34 · 38.2%Moderate 18 · 20.2%High 7 · 7.9%

Platinum doublet vs non‐platinum therapy

Toxicity – thrombocytopenia grade 3–5 · people with advanced non‐small cell lung cancer, performance status 2 without a targetable mutation or with an unknown mutation status

Platinum doublet may leads to higher toxicity – thrombocytopenia grade 3–5 compared with non‐platinum therapy (low certainty).

1 finding from 1 review

Double‐balloon catheter vs vaginal PGE2

Caesarean section · women with a previous caesarean section (subgroup of all women in the study) with intact fetal membranes, cephalic position and…

It is very uncertain whether double‐balloon catheter changes caesarean section compared with vaginal PGE2 (very low certainty).

1 finding from 1 review

Procedures: doffing with double gloves vs doffing with single gloves

Contamination: virus detected ‐ All body parts · healthcare workers

It is very uncertain whether procedures: doffing with double gloves changes contamination: virus detected ‐ all body parts compared with doffing with single gloves (very low certainty).

1 finding from 1 review

Procedures: doffing with double gloves vs doffing with single gloves

Contamination: virus detected ‐ face · healthcare workers

It is very uncertain whether procedures: doffing with double gloves changes contamination: virus detected ‐ face compared with doffing with single gloves (very low certainty).

1 finding from 1 review

Procedures: doffing with double gloves vs doffing with single gloves

Contamination: virus detected ‐ shirt · healthcare workers

It is very uncertain whether procedures: doffing with double gloves changes contamination: virus detected ‐ shirt compared with doffing with single gloves (very low certainty).

1 finding from 1 review

Procedures: doffing with double gloves vs doffing with single gloves

Contamination: virus detected ‐ pants · healthcare workers

It is very uncertain whether procedures: doffing with double gloves changes contamination: virus detected ‐ pants compared with doffing with single gloves (very low certainty).

1 finding from 1 review

Procedures: doffing with double gloves vs doffing with single gloves

Compliance with guidance ‐ Noncompliance: any error · healthcare workers

It is very uncertain whether procedures: doffing with double gloves changes non‐compliance: any error compared with doffing with single gloves (very low certainty).

1 finding from 1 review

Procedures: doffing with double gloves vs doffing with single gloves

Contamination with fluorescent · healthcare workers

It is very uncertain whether procedures: doffing with double gloves changes contamination with fluorescent compared with doffing with single gloves (very low certainty).

1 finding from 1 review

Padded moulded double‐rocker plaster shoe vs padded below‐knee plaster

Ulcer healing · ulceration and other skin changes caused by nerve damage in leprosy

It is very uncertain whether padded moulded double‐rocker plaster shoe changes primary outcome: healing of ulcer (ulcers fully or nearly healed at… compared with padded below‐knee plaster (very low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

Post‐ERCP pancreatitis · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) may leads to higher post‐ERCP pancreatitis compared with other endoscopic techniques (low certainty).

1 finding from 1 review

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) vs other endoscopic techniques

CBD cannulation success with the randomised technique (before the use of rescue techniques) · people with biliary cannulation for the prevention of post‐ERCP pancreatitis

Pancreatic duct guidewire (PGW) or double guidewire technique (DGT) showed no clear difference in CBD cannulation success with the randomised technique (before the… compared with other endoscopic techniques (low certainty).

1 finding from 1 review