Function · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents
1 finding from 1 review
Number of serious adverse events · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents
It is very uncertain whether anti‐TNF discontinuation changes number of serious adverse events compared with anti‐TNF continuation (very low certainty).
1 finding from 1 review
Withdrawals due to adverse events · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents
Anti‐TNF discontinuation showed no clear difference in withdrawals due to adverse events compared with anti‐TNF continuation (moderate certainty).
1 finding from 1 review
Disease activity · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents
1 finding from 1 review
Maintenance of clinical remission · people with rheumatoid arthritis with low disease activity using a standard dose of anti‐TNF agents
Anti‐TNF discontinuation may leads to lower proportion of participants with persistent remission compared with anti‐TNF continuation (low certainty).
1 finding from 1 review
Global state: 2. Clinically important change (no improvement) ‐ long term · schizophrenia
It is very uncertain whether haloperidol discontinuation changes global state: clinically important change ‒ not improved (CGI) compared with haloperidol continuation (very low certainty).
1 finding from 1 review
Relapse · schizophrenia
It is very uncertain whether haloperidol discontinuation changes global state: relapse: ‒ compared with haloperidol continuation (very low certainty).
1 finding from 1 review
Mental state: clinically important change in mental state · schizophrenia
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
General functioning: clinically important change in general functioning including working ability · schizophrenia
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Behaviour: clinically important change in general behaviour · schizophrenia
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Quality of life: clinically important change in quality of life · schizophrenia
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Satisfaction with treatment: leaving the study early Endpoint data (events) · schizophrenia
It is very uncertain whether haloperidol discontinuation changes satisfaction with treatment: leaving the study early compared with haloperidol continuation (very low certainty).
1 finding from 1 review
Relapse · participants with depressive or anxiety disorders
It is very uncertain whether discontinuation by "tapering" changes relapse (as defined by study authors) (HR) compared with continuation (or usual care) (very low certainty).
1 finding from 1 review
Withdrawal symptoms · participants with depressive or anxiety disorders
1 finding from 1 review
Adverse events · participants with depressive or anxiety disorders
It is very uncertain whether discontinuation by "tapering" changes adverse events compared with continuation (or usual care) (very low certainty).
1 finding from 1 review
Depressive symptoms · participants with depressive or anxiety disorders
1 finding from 1 review
Anxiety · participants with depressive or anxiety disorders
1 finding from 1 review
Quality of life · participants with depressive or anxiety disorders
1 finding from 1 review
Social and occupational functioning · participants with depressive or anxiety disorders
1 finding from 1 review
All‐cause mortality · febrile neutropenia
Early discontinuation of antibiotic treatment showed no clear difference in mortality compared with treatment until neutropenia resolution (low certainty).
1 finding from 1 review