Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

165 questions · 173 findings · 17 reviews

No studies found 45 · 26%GRADE not reported 12 · 6.9%Very low 37 · 21.4%Low 50 · 28.9%Moderate 25 · 14.5%High 4 · 2.3%

Continuous positive airway pressure (CPAP) plus best supportive care vs best supportive care

Cardiovascular mortality

Continuous positive airway pressure (CPAP) plus best supportive care showed no clear difference in cardiovascular mortality ‐ after 24 months Number of participants:… compared with best supportive care (low certainty).

1 finding from 1 review

Continuous positive airway pressure (CPAP) plus best supportive care vs best supportive care

All‐cause mortality ‐ after 24 months Number of participants: 287(2 RCTs)

It is very uncertain whether continuous positive airway pressure (CPAP) plus best supportive care changes all‐cause mortality ‐ after 24 months Number of participants: 287(2… compared with best supportive care (very low certainty).

1 finding from 1 review

Continuous positive airway pressure (CPAP) plus best supportive care vs best supportive care

Time to life‐saving cardiovascular intervention

Continuous positive airway pressure (CPAP) plus best supportive care may leads to lower time to life‐saving cardiovascular intervention ( compared with best supportive care (low certainty).

1 finding from 1 review

NIPPV vs NCPAP

Respiratory failure post extubation · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) probably leads to lower respiratory failure postextubation compared with nasal continuous positive airway pressure (NCPAP) (moderate certainty).

1 finding from 1 review

NIPPV vs NCPAP

Gastrointestinal perforation · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in gastrointestinal perforation compared with nasal continuous positive airway pressure (NCPAP) (low certainty).

1 finding from 1 review

NIPPV vs NCPAP

Necrotising enterocolitis · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in necrotising enterocolitis compared with nasal continuous positive airway pressure (NCPAP) (moderate certainty).

1 finding from 1 review

NIPPV vs NCPAP

Chronic lung disease · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in chronic lung disease (oxygen supplementation at 36 weeks) compared with nasal continuous positive airway pressure (NCPAP) (moderate certainty).

1 finding from 1 review

NIPPV vs NCPAP

Mortality before hospital discharge · preterm neonates after extubation

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in mortality (defined as death before discharge) compared with nasal continuous positive airway pressure (NCPAP) (low certainty).

1 finding from 1 review

NIPPV vs NCPAP

Need for endotracheal tube ventilation · )

Nasal intermittent positive pressure ventilation (NIPPV) probably leads to lower need for endotracheal tube ventilation compared with nasal continuous positive airway pressure (NCPAP) (by population) (moderate certainty).

1 finding from 1 review

NIPPV vs NCPAP

Severe (grade 3 or greater) intraventricular hemorrhage (IVH) on cranial ultrasound ‐ not reported · )

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in severe intraventricular hemorrhage (grade III/IV) compared with nasal continuous positive airway pressure (NCPAP) (by population) (low certainty).

1 finding from 1 review