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Evidence found and GRADE certainty

31 questions · 34 findings · 9 reviews

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No studies found 7 · 20.6%GRADE not reported 5 · 14.7%Very low 4 · 11.8%Low 8 · 23.5%Moderate 10 · 29.4%High 0 · 0%

Summary of findings table ‐ Topical capsaicin vs placebo

Present pain of TMD (VAS) · Adult patients aged >=18 years, clinically or radiographically diagnosed with TMD (McNeill 1997 criteria); moderate to severe pain of…

Topical capsaicin (0.025% cream) showed no clear difference in present pain of TMD (VAS) compared with placebo; GRADE not reported.

1 finding from 1 review

Topical treatments (capsaicin oral rinse) vs placebo

Relief of burning/discomfort (symptom relief; pain intensity) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
2 findings from 1 review
  • Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
    short-term (up to 3 months) · capsaicin oral rinse
    Capsaicin oral rinse (Marino 2010; Silvestre 2012) contributes to the topical treatments short-term symptom-relief comparison (insufficient/contradictory). Silvestre 2012 data not presented due to 23% first-phase…
    1 study
    GRADE not reported
  • Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
    long-term (>3 to 6 months) · capsaicin oral rinse
    MD -2.60 [-5.11, -0.09]
    1 study · 18 participants
    Very low

Summary of findings table ‐ Topical capsaicin vs placebo

Risk for at least one adverse event per patient · patients with chronic kidney disease (CKD) pruritus

Summary of findings table ‐ Topical capsaicin may leads to higher risk for at least one adverse event per patient compared with placebo (low certainty).

1 finding from 1 review