Adverse events: including serious adverse events, vaso‐occlusive crisis, gastrointestinal disorder, headache or migraine, upper respiratory tract infection, rash · people with sickle cell disease
1 finding from 1 review
SCD‐related SAEs ‐ pain crisis · prevention of SCI in people with SCD and abnormal TCD velocities
It is very uncertain whether long‐term RBC transfusion changes SCD‐related SAEs ‐ pain crisis compared with standard care (very low certainty).
1 finding from 1 review
SCD‐related SAEs ‐ pain crisis · SCD‐related SAEs and clinical stroke in people with SCD at risk of stroke and no previous long‐term RBC transfusions
Long‐term RBC transfusions may leads to lower SCD‐related SAEs ‐ pain crisis compared with standard care (low certainty).
1 finding from 1 review
SCD‐related SAEs ‐ pain crisis · prevention of SCI in people with SCD and normalised TCD velocities
1 finding from 1 review
SCD‐related SAEs ‐ pain crisis · prevention of SCI in people with SCD who have not had a stroke (primary prevention)
It is very uncertain whether hydroxyurea changes SCD‐related SAEs ‐ pain crisis compared with RBC transfusions (very low certainty).
1 finding from 1 review
SCD‐related SAEs ‐ pain crisis · prevention of SCI in people with SCD who had a stroke (secondary prevention)
Hydroxyurea may leads to higher SCD‐related SAEs ‐ pain crisis compared with RBC transfusion (low certainty).
1 finding from 1 review
SCD‐related SAEs ‐ pain crisis · prevention of SCI in people with SCD and normal TCD velocities
Long‐term RBC transfusion may leads to lower SCD‐related SAEs ‐ pain crisis compared with standard care (low certainty).
1 finding from 1 review
PGIC very much improved · adults with sickle cell disease in a vaso‐occlusive crisis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Patient Global Impression of Change much or very much improved · adults with sickle cell disease in a vaso‐occlusive crisis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Any adverse event · adults with sickle cell disease in a vaso‐occlusive crisis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Serious adverse event · adults with sickle cell disease in a vaso‐occlusive crisis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Withdrawals due to adverse events · adults with sickle cell disease in a vaso‐occlusive crisis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Participant‐reported pain relief of 50% or greater · adults with sickle cell disease in a vaso‐occlusive crisis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Participant‐reported pain relief of 30% or greater · adults with sickle cell disease in a vaso‐occlusive crisis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
PGIC very much improved · adults with sickle cell disease in a vaso‐occlusive crisis
1 finding from 1 review
Patient Global Impression of Change much or very much improved · adults with sickle cell disease in a vaso‐occlusive crisis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Any adverse event ( · adults with sickle cell disease in a vaso‐occlusive crisis
1 finding from 1 review
Serious adverse event ( · adults with sickle cell disease in a vaso‐occlusive crisis
1 finding from 1 review
Withdrawals due to adverse events · adults with sickle cell disease in a vaso‐occlusive crisis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Participant‐reported pain relief of 50% or greater · adults with sickle cell disease in a vaso‐occlusive crisis
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found