Findings

What do systematic reviews say?

26 questions · 26 findings · 1 reviews · Dental caries

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No studies found 10 · 38.5%GRADE not reported 0 · 0%Very low 8 · 30.8%Low 8 · 30.8%Moderate 0 · 0%High 0 · 0%

Professionally-applied 12,300 ppm F APF foam, every 2 months vs 0 ppm F placebo foam

Number of participants with more severe DLs (severity of DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

The review found no eligible studies for this question.

1 finding from 1 review

Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes
At debond (end of orthodontic treatment)
SoF 2. Number of participants with more severe DLs: none of the trials reported this outcome.
0 studies
No studies found

12,500 ppm F (NaF/olaflur/dectaflur) amine fluoride gel vs Placebo gel

Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

1 finding from 1 review

Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes
At debond; mean follow-up 16.6 months
Additional SoF Table 1. Adverse effects: with placebo gel 0.60%; with fluoride gel 0.00% (0 to 0); difference 0.60% fewer (0.60 fewer to 0.60 fewer); relative effect not estimable; 312 participants (1 RCT); certainty…
1 study · 312 participants
Very low

Professionally-applied 12,300 ppm F APF foam, every 2 months vs 0 ppm F placebo foam

Number of participants with new demineralised lesions (DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Professionally-applied 12,300 ppm F APF foam, every 2 months may leads to lower number of participants with new demineralised lesions (DLs) compared with 0 ppm F placebo foam (low certainty).

1 finding from 1 review

Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes
At debond; mean follow-up 18 months
RR 0.26 [0.11, 0.57]
1 study · 95 participants
Low

1400/250 ppm F (amine F/SnF2) toothpaste + mouthrinse, daily vs 1400/250 ppm F (NaF) toothpaste + mouthrinse, daily

Plaque index (PI) / oral hygiene · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

It is very uncertain whether 1400/250 ppm F (amine F/SnF2) toothpaste + mouthrinse, daily changes visible plaque index (mean change from baseline) compared with 1400/250 ppm F (NaF) toothpaste + mouthrinse, daily (very low certainty).

1 finding from 1 review

Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes
At debond; follow-up 1.5 years
MD -0.09 [-0.18, 0]
1 study · 97 participants
Very low

Professionally-applied 12,300 ppm F APF foam, every 2 months vs 0 ppm F placebo foam

Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

The review found no eligible studies for this question.

1 finding from 1 review

Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes
At debond (end of orthodontic treatment)
SoF 2. Adverse effects: none of the trials reported this outcome.
0 studies
No studies found

Fluoride varnish vs Non-fluoride (placebo) varnish

Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

1 finding from 1 review

Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes
At debond; follow-up 1.7 years
SoF 1. Adverse effects: no evidence that the intervention had adverse effects; only 1 participant with an adverse event and unclear if directly related to the intervention. 148 participants (1 RCT, Sonesson 2019);…
1 study · 148 participants
Low