Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

50 questions · 54 findings · 4 reviews · Heart

No studies found 8 · 14.8%GRADE not reported 0 · 0%Very low 7 · 13%Low 15 · 27.8%Moderate 15 · 27.8%High 9 · 16.7%

Intervention not reported

All‐cause mortality at maximum · patients without heart failure

The intervention probably leads to lower all‐cause mortality at maximum (moderate certainty).

1 finding from 1 review

Intervention not reported

Major cardiovascular events (cardiovascular mortality or non‐fatal myocardial infarction) at maximum · patients without heart failure

The intervention may leads to lower major cardiovascular events (cardiovascular mortality or non‐fatal… (low certainty).

1 finding from 1 review

Intervention not reported

Myocardial infarction at maximum · patients without heart failure

The intervention probably leads to lower myocardial infarction at maximum (moderate certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs placebo or no treatment

Cardiovascular mortality · patients with chronic heart failure with preserved ejection fraction

Angiotensin‐converting enzyme inhibitors (ACEIs) showed no clear difference in cardiovascular mortality (RR) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs placebo or no treatment

Heart failure hospitalisation (RR) · patients with chronic heart failure with preserved ejection fraction

Angiotensin‐converting enzyme inhibitors (ACEIs) showed no clear difference in heart failure hospitalisation (RR) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Angiotensin‐converting enzyme inhibitors vs placebo or no treatment

All‐cause mortality (RR) · patients with chronic heart failure with preserved ejection fraction

Angiotensin‐converting enzyme inhibitors (ACEIs) showed no clear difference in all‐cause mortality (RR) compared with placebo or no treatment (moderate certainty).

1 finding from 1 review

Angiotensin receptor blockers (ARBs) vs placebo or no treatment

Cardiovascular mortality · patients with chronic heart failure with preserved ejection fraction

Angiotensin receptor blockers (ARBs) showed no clear difference in cardiovascular mortality (RR) compared with placebo or no treatment (high certainty).

1 finding from 1 review

Angiotensin receptor blockers (ARBs) vs placebo or no treatment

Heart failure hospitalisation (RR) · patients with chronic heart failure with preserved ejection fraction

Angiotensin receptor blockers (ARBs) showed no clear difference in heart failure hospitalisation (RR) compared with placebo or no treatment (high certainty).

1 finding from 1 review

Angiotensin receptor blockers (ARBs) vs placebo or no treatment

Hyperkalaemia · patients with chronic heart failure with preserved ejection fraction

Angiotensin receptor blockers (ARBs) leads to higher hyperkalaemia compared with placebo or no treatment (high certainty).

1 finding from 1 review

Angiotensin receptor blockers (ARBs) vs placebo or no treatment

All‐cause mortality (RR) · patients with chronic heart failure with preserved ejection fraction

Angiotensin receptor blockers (ARBs) showed no clear difference in all‐cause mortality (RR) compared with placebo or no treatment (high certainty).

1 finding from 1 review