Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

38 questions · 38 findings · 3 reviews · Kidney and Transplant

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 5 · 13.2%Low 13 · 34.2%Moderate 19 · 50%High 1 · 2.6%

Antibody (T cell) vs steroids

Treatment adverse events: fever, chills, malaise after drug administration · kidney transplant recipients: first rejection episode

It is very uncertain whether antibody (T cell) changes treatment adverse events: fever, chill, or malaise after drug… compared with steroid (stratified by antibody type) (very low certainty).

1 finding from 1 review

Polyclonal T‐cell antibody induction vs interleukin‐2 receptor antagonist induction

Bronchiolitis obliterans syndrome · lung transplant recipients

Polyclonal T‐cell antibody induction showed no clear difference in bronchiolitis obliterans syndrome compared with interleukin‐2 receptor antagonist induction (moderate certainty).

1 finding from 1 review

Antibody (T cell) + steroid vs steroids

Graft loss or death with a functioning graft · kidney transplant recipients: first rejection episode

It is very uncertain whether antibody (T cell) + steroid changes graft loss or death with a functioning graft compared with steroid alone (very low certainty).

1 finding from 1 review

Mycophenolate mofetil vs azathioprine (AZA)

Acute rejection, steroid resistant/antibody treated As reported in the articles · patients with kidney transplant recipients

Mycophenolate mofetil (MMF) leads to lower acute rejection, steroid resistant/antibody treated As reported in… compared with azathioprine (AZA) (high certainty).

1 finding from 1 review

Muromonab‐CD3 (T cell) vs other antibody (stratified by comparator)

Failure of acute rejection reversal · kidney transplant recipients: first rejection episode

Muromonab‐CD3 (T cell) showed no clear difference in failure of acute rejection reversal compared with other antibody (stratified by comparator) (moderate certainty).

1 finding from 1 review

Muromonab‐CD3 (T cell) vs other antibody (stratified by comparator)

Recurrent rejection · kidney transplant recipients: first rejection episode

Muromonab‐CD3 (T cell) showed no clear difference in recurrent rejection compared with other antibody (stratified by comparator) (moderate certainty).

1 finding from 1 review

Muromonab‐CD3 (T cell) vs other antibody (stratified by comparator)

Treatment adverse events: fever, chills, malaise after drug administration · kidney transplant recipients: first rejection episode

Muromonab‐CD3 (T cell) may leads to higher treatment adverse events: fever, chills, malaise after drug… compared with other antibody (stratified by comparator) (low certainty).

1 finding from 1 review

Muromonab‐CD3 (T cell) vs other antibody (stratified by comparator)

Neurological adverse effects · kidney transplant recipients: first rejection episode

Muromonab‐CD3 (T cell) may leads to higher treatment adverse events: neurological side effects compared with other antibody (stratified by comparator) (low certainty).

1 finding from 1 review