Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

143 questions · 144 findings · 18 reviews · Headline outcomes only

No studies found 8 · 5.6%GRADE not reported 1 · 0.7%Very low 32 · 22.2%Low 65 · 45.1%Moderate 32 · 22.2%High 6 · 4.2%

Antibody (T cell) vs steroids

Graft loss or death with a functioning graft · kidney transplant recipients: first rejection episode

Antibody (T cell) showed no clear difference in graft loss or death with a functioning graft compared with steroid (stratified by antibody type) (low certainty).

1 finding from 1 review

Antibody (T cell) vs steroids

Treatment adverse events: fever, chills, malaise after drug administration · kidney transplant recipients: first rejection episode

It is very uncertain whether antibody (T cell) changes treatment adverse events: fever, chill, or malaise after drug… compared with steroid (stratified by antibody type) (very low certainty).

1 finding from 1 review

T‐cell antibody induction vs corticosteroid induction

Infection Number of participants who experienced at least 1 episode of infection · liver transplant recipients

T‐cell antibody induction showed no clear difference in infection Number of participants who experienced at least 1 episode… compared with corticosteroid induction (low certainty).

1 finding from 1 review

T‐cell antibody induction vs corticosteroid induction

Hepatitis C recurrence Number of participants diagnosed with hepatitis C virus recurrence · liver transplant recipients

T‐cell antibody induction showed no clear difference in hepatitis C recurrence Number of participants diagnosed with… compared with corticosteroid induction (low certainty).

1 finding from 1 review

T‐cell antibody induction vs placebo or no intervention

Graft loss including death · liver transplant recipients

T‐cell antibody induction may leads to lower graft loss including death Graft loss including death at latest compared with placebo/no intervention (low certainty).

1 finding from 1 review

T‐cell antibody induction vs placebo or no intervention

Acute rejection · liver transplant recipients

T‐cell antibody induction probably leads to lower acute rejection Number of participants who experienced at least 1… compared with placebo/no intervention (moderate certainty).

1 finding from 1 review