Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

155 questions · 166 findings · 21 reviews

No studies found 10 · 6%GRADE not reported 19 · 11.4%Very low 32 · 19.3%Low 65 · 39.2%Moderate 34 · 20.5%High 6 · 3.6%

Antibody (T cell) vs steroids

Graft loss or death with a functioning graft · kidney transplant recipients: first rejection episode

Antibody (T cell) showed no clear difference in graft loss or death with a functioning graft compared with steroid (stratified by antibody type) (low certainty).

1 finding from 1 review

Antibody (T cell) vs steroids

Treatment adverse events: fever, chills, malaise after drug administration · kidney transplant recipients: first rejection episode

It is very uncertain whether antibody (T cell) changes treatment adverse events: fever, chill, or malaise after drug… compared with steroid (stratified by antibody type) (very low certainty).

1 finding from 1 review

Anticaries vaccine or antibody (DNA, recombinant protein, nanoparticle-adjuvanted, live-vector, plant-based, or passive IgY immunization) targeting S. mutans vs Control (unvaccinated / empty vector / PBS / placebo animals)

Salivary / secretory IgA (SIgA) antibody response (immunogenicity) · Animal caries models (mice, rats, hamsters) challenged/colonized with Streptococcus mutans; one transgenic-plant antigen-expression system

Anticaries vaccines, particularly via mucosal (intranasal) routes, elicited increased salivary/secretory IgA responses in the animal studies (ungraded narrative synthesis; no pooled estimate).

1 finding from 1 review

Anticaries vaccine or antibody (DNA, recombinant protein, nanoparticle-adjuvanted, live-vector, plant-based, or passive IgY immunization) targeting S. mutans vs Control (unvaccinated / empty vector / PBS / placebo animals)

Serum IgG antibody response (immunogenicity) · Animal caries models (mice, rats, hamsters) challenged/colonized with Streptococcus mutans; one transgenic-plant antigen-expression system

Anticaries vaccines elicited increased serum IgG antibody responses across the animal studies (ungraded narrative synthesis; no pooled estimate).

1 finding from 1 review

T‐cell antibody induction vs corticosteroid induction

Infection Number of participants who experienced at least 1 episode of infection · liver transplant recipients

T‐cell antibody induction showed no clear difference in infection Number of participants who experienced at least 1 episode… compared with corticosteroid induction (low certainty).

1 finding from 1 review

T‐cell antibody induction vs corticosteroid induction

Hepatitis C recurrence Number of participants diagnosed with hepatitis C virus recurrence · liver transplant recipients

T‐cell antibody induction showed no clear difference in hepatitis C recurrence Number of participants diagnosed with… compared with corticosteroid induction (low certainty).

1 finding from 1 review

T‐cell antibody induction vs placebo or no intervention

Graft loss including death · liver transplant recipients

T‐cell antibody induction may leads to lower graft loss including death Graft loss including death at latest compared with placebo/no intervention (low certainty).

1 finding from 1 review

T‐cell antibody induction vs placebo or no intervention

Acute rejection · liver transplant recipients

T‐cell antibody induction probably leads to lower acute rejection Number of participants who experienced at least 1… compared with placebo/no intervention (moderate certainty).

1 finding from 1 review