Percentage of closed pockets · Adults with periodontitis (chronic and aggressive)
Amoxicillin + metronidazole + SRP led to lower percentage of closed pockets compared with SRP; GRADE not reported.
3 findings from 1 review
MD -13.90 [-24.16, -3.64]
1 study · 44 participants
GRADE not reported
MD -16.20 [-25.87, -6.53]
1 study · 44 participants
Very low
MD -10.05 [-18.78, -1.32]
2 studies · 73 participants
GRADE not reported
Patient-reported quality of life changes · Adults with periodontitis (chronic and aggressive)
The review found no eligible studies for this question.
1 finding from 1 review
Percentage of bleeding on probing (BOP) · Adults with aggressive periodontitis
Amoxicillin + metronidazole + SRP showed no clear difference in percentage of bleeding on probing (BOP) compared with clarithromycin + SRP; GRADE not reported.
2 findings from 1 review
Antimicrobial resistance · Adults with periodontitis (chronic and aggressive)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse events · Adults with periodontitis (chronic and aggressive)
It is very uncertain whether amoxicillin + metronidazole + SRP changes adverse events compared with SRP (very low certainty).
1 finding from 1 review
Most common adverse events were mild gastrointestinal disturbances, nausea and vomiting, metallic taste, and diarrhoea in the intervention group. Control group reported adverse events like hypothermia, mild…
2 studies · 389 participants
Very low
Neonatal mortality · neonates with fast breathing alone
Comparison 2: 7 days oral amoxicillin showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (low certainty).
1 finding from 1 review
Early neonatal mortality · neonates with fast breathing alone
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Late neonatal mortality · neonates with fast breathing alone
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Sepsis‐specific neonatal mortality · neonates with fast breathing alone
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Treatment failure · neonates with fast breathing alone
Comparison 2: 7 days oral amoxicillin showed no clear difference in treatment failure compared with 7 days injectable benzylpenicillin + injectable gentamicin (low certainty).
1 finding from 1 review
Adverse events · neonates with fast breathing alone
1 finding from 1 review
Prosthesis failure · Adults undergoing dental implant placement
Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in prosthesis failure compared with no antibiotics or placebo; GRADE not reported.
1 finding from 1 review
Postoperative infection · Adults undergoing dental implant placement
Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in postoperative infection compared with no antibiotics or placebo; GRADE not reported.
1 finding from 1 review
Implant failure · Adults undergoing dental implant placement
Prophylactic systemic antibiotics (amoxicillin) probably leads to lower implant failure compared with no antibiotics or placebo (moderate certainty).
1 finding from 1 review
Adverse events · Adults undergoing dental implant placement
Prophylactic systemic antibiotics (amoxicillin) showed no clear difference in adverse events compared with no antibiotics or placebo; GRADE not reported.
1 finding from 1 review
Neonatal mortality · neonates with possible serious bacterial infection
Comparison 2: 7 days oral amoxicillin + injectable gentamicin showed no clear difference in neonatal mortality compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).
1 finding from 1 review
Early neonatal mortality · neonates with possible serious bacterial infection
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Late neonatal mortality · neonates with possible serious bacterial infection
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Sepsis‐specific neonatal mortality · neonates with possible serious bacterial infection
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Treatment failure · neonates with possible serious bacterial infection
Comparison 2: 7 days oral amoxicillin + injectable gentamicin showed no clear difference in treatment failure compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).
1 finding from 1 review