Amoxicillin + metronidazole + SRP vs SRP: Adverse events
- Population
- Adults with periodontitis (chronic and aggressive)
- Intervention
- Amoxicillin + metronidazole + SRP
- Comparison
- SRP
- Outcome
- Adverse events
It is very uncertain whether amoxicillin + metronidazole + SRP changes adverse events compared with SRP (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Amoxicillin + metronidazole + SRP vs SRP Adverse events · Adults with periodontitis (chronic and aggressive) · Long-term (≥ 1 year) It is very uncertain whether amoxicillin + metronidazole + SRP changes adverse events compared with SRP (very low certainty). Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis (2020) · Cochrane All outcomes | Most common adverse events were mild gastrointestinal disturbances, nausea and vomiting, metallic taste, and diarrhoea in the intervention group. Control group reported adverse events like hypothermia, mild… | 2 studies · 389 participants | Very low |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes | 2020-03 | Not listed | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- Amoxicillin + metronidazole + SRP vs Clarithromycin + SRP · Adults with aggressive periodontitis · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.