Surgical intervention · men with lower urinary tract symptoms secondary to benign prostatic obstruction
It is very uncertain whether combination therapy changes surgical intervention compared with alpha‐blockers (very low certainty).
1 finding from 1 review
Urologic symptom scores · men with lower urinary tract symptoms secondary to benign prostatic obstruction
1 finding from 1 review
QoL · men with lower urinary tract symptoms secondary to benign prostatic obstruction
1 finding from 1 review
Adverse events · men with lower urinary tract symptoms secondary to benign prostatic obstruction
Combination therapy showed no clear difference in adverse events compared with alpha‐blockers (low certainty).
1 finding from 1 review
AUR · men with lower urinary tract symptoms secondary to benign prostatic obstruction
Combination therapy showed no clear difference in AUR compared with alpha‐blockers (low certainty).
1 finding from 1 review
Total mortality Duration: 3.2 years · patients with hypertension
First‐line thiazides showed no clear difference in total mortality Duration: 3.2 years compared with first‐line alpha‐blockers (moderate certainty).
1 finding from 1 review
Total serious adverse events · patients with hypertension
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Cardiovascular events · patients with hypertension
First‐line thiazides probably leads to lower total cardiovascular events Duration: 3 to 3.2 years compared with first‐line alpha‐blockers (moderate certainty).
1 finding from 1 review
Stroke · patients with hypertension
First‐line thiazides showed no clear difference in total stroke Duration: 3 to 3.2 years compared with first‐line alpha‐blockers (moderate certainty).
1 finding from 1 review
Total CHD Duration: 1 to 5.8 years · patients with hypertension
First‐line thiazides showed no clear difference in total CHD Duration: 3 to 3.2 years compared with first‐line alpha‐blockers (low certainty).
1 finding from 1 review
Congestive heart failure · patients with hypertension
First‐line thiazides probably leads to lower total congestive heart failure Duration: 3.2 years compared with first‐line alpha‐blockers (moderate certainty).
1 finding from 1 review
Withdrawals due to adverse events · patients with hypertension
First‐line thiazides may leads to lower withdrawals due to adverse effects Duration: 1 to 3.2 years compared with first‐line alpha‐blockers (low certainty).
1 finding from 1 review
Symptom score for LUTS · men with lower urinary tract symptoms secondary to benign prostatic obstruction
1 finding from 1 review
Response rate · men with lower urinary tract symptoms secondary to benign prostatic obstruction
It is very uncertain whether physical activity changes response rate compared with alpha‐blockers (very low certainty).
1 finding from 1 review
Withdrawals due to adverse events · men with lower urinary tract symptoms secondary to benign prostatic obstruction
Physical activity showed no clear difference in withdrawal due to adverse events compared with alpha‐blockers (low certainty).
1 finding from 1 review
IPSS‐total score
1 finding from 1 review
BPHII score
1 finding from 1 review
Adverse events
PDEI showed no clear difference in adverse events compared with alpha‐blockers (low certainty).
1 finding from 1 review
IPSS‐total score
1 finding from 1 review
BPHII score
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found