First‐line thiazides vs alpha‐blocker: Stroke
- Population
- patients with hypertension
- Intervention
- First‐line thiazides
- Comparison
- alpha‐blocker
- Outcome
- Stroke
First‐line thiazides showed no clear difference in total stroke Duration: 3 to 3.2 years compared with first‐line alpha‐blockers (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
First‐line thiazides vs first‐line alpha‐blockers Total stroke Duration: 3 to 3.2 years · adults with hypertension First‐line thiazides showed no clear difference in total stroke Duration: 3 to 3.2 years compared with first‐line alpha‐blockers (moderate certainty). First‐line diuretics versus other classes of antihypertensive drugs for hypertension (2023) · Cochrane Headline outcomes only | RR 0.86 [0.73, 1.01] | 2 studies · 24396 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| First‐line diuretics versus other classes of antihypertensive drugs for hypertension 2023 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
Related questions
The same intervention and outcome, asked in another population or against another comparator.
- First‐line thiazides vs calcium channel blockers · patients with hypertension · 1 review
- First‐line thiazides vs ACE inhibitor · patients with hypertension · 1 review
- First‐line thiazides vs beta‐blocker · patients with hypertension · 1 review
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.