Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

208 questions · 270 findings · 18 reviews

No studies found 69 · 25.6%GRADE not reported 121 · 44.8%Very low 50 · 18.5%Low 24 · 8.9%Moderate 6 · 2.2%High 0 · 0%

Higher circulating 25-hydroxyvitamin D (25(OH)D) concentration vs Lower circulating 25-hydroxyvitamin D (25(OH)D) concentration

Aggressive prostate cancer · Adults (general population)

Meta-analysis of observational studies (higher vs lower 25(OH)D) for Aggressive prostate cancer: OR 0.98 (95% CI 0.84 to 1.15), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.

1 finding from 1 review

Higher circulating 1,25-dihydroxyvitamin D (1,25(OH)2D) concentration vs Lower circulating 1,25-dihydroxyvitamin D (1,25(OH)2D) concentration

Aggressive prostate cancer · Adults (general population)

Meta-analysis of observational studies (higher vs lower 1,25(OH)2D) for Aggressive prostate cancer: OR 0.75 (95% CI 0.48 to 1.17), not statistically significant. Umbrella review outcome-level evidence grade: Substantial effect unlikely.

1 finding from 1 review

Structured risk assessment vs usual care

Use of coercive measure: use of seclusion room (participants) · aggressive behaviour in schizophrenia

Structured risk assessment showed no clear difference in use of coercive measure: use of seclusion room (participants) compared with standard professional care (low certainty).

1 finding from 1 review

Summary of findings table ‐ Positive behavioural support vs treatment

Mental state: Common Mental Disorder (CMD) – at 6 months (Analysis 2.2.1) (CMD) · outwardly aggressive behaviour in people with intellectual disability

Summary of findings table ‐ Positive behavioural support showed no clear difference in mental state: Common Mental Disorder (CMD) – at 6 months (Analysis… compared with treatment (low certainty).

1 finding from 1 review

Summary of findings table ‐ Anger management vs waiting list control

Ability to control anger: Provocation Inventory (PI) ‐ self report: Post‐treatment (scale range 0 to 75; higher scores indicate higher levels of aggression) · outwardly aggressive behaviour in people with intellectual disability
1 finding from 1 review

Summary of findings table ‐ Mindfulness based on positive behaviour support vs positive behaviour support

Ability to control anger ‐ not measured · outwardly aggressive behaviour in people with intellectual disability

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Mindfulness based on positive behaviour support vs positive behaviour support

Adaptive functioning ‐ not measured · outwardly aggressive behaviour in people with intellectual disability

The review found no eligible studies for this question.

1 finding from 1 review