Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

537 questions · 558 findings · 32 reviews · Gut

No studies found 134 · 24%GRADE not reported 11 · 2%Very low 143 · 25.6%Low 138 · 24.7%Moderate 106 · 19%High 26 · 4.7%

Active drain vs passive drain

Length of hospital stay · people undergoing elective pancreatic resections

It is very uncertain whether active drain changes length of hospital stay compared with passive drain following pancreatic surgery (very low certainty).

1 finding from 1 review

Active drain vs passive drain

All‐cause mortality · people undergoing elective pancreatic resections

It is very uncertain whether active drain changes mortality compared with passive drain following pancreatic surgery (very low certainty).

2 findings from 1 review

Oral iron sulphate vs oral iron hydroxide polymaltose complex

Serious adverse events ‐ active or inactive disease (14 days) · IBD patients

It is very uncertain whether oral iron sulphate changes serious adverse events ‐ active or inactive disease (14 days) compared with oral iron hydroxide polymaltose complex (very low certainty).

1 finding from 1 review

Intervention not reported

H. pylori eradication therapy versus no active treatment · people with Helicobacter pylori‐positive peptic ulcer

The intervention may leads to lower H. pylori eradication therapy versus no active treatment (low certainty).

1 finding from 1 review

Intervention not reported

H. pylori eradication therapy versus no active treatment · prevention of recurrence in people with Helicobacter pylori‐positive peptic ulcer

It is very uncertain whether the intervention changes H. pylori eradication therapy versus no active treatment (very low certainty).

1 finding from 1 review

Intervention not reported

Colonic transit rate (geometric centre of radioactive substance). Unit indicates position along with intestinal tract. Scale from: 1 (small intestine) to 5 (rectosigmoid area). · children with chronic constipation
1 finding from 1 review

Subcutaneous CT‐P13 and purine analogues vs intravenous CT‐P13 and purine analogues

Clinical relapse · patients with Crohn's disease (active disease population with clinical response at baseline)

It is very uncertain whether subcutaneous CT‐P13 and purine analogues changes clinical relapse (at 22 weeks, CDAI > 150) compared with intravenous CT‐P13 and purine analogues (very low certainty).

1 finding from 1 review

Subcutaneous CT‐P13 and purine analogues vs intravenous CT‐P13 and purine analogues

Loss of clinical response (at 22 weeks, less than 100 points in CDAI change) · patients with Crohn's disease (active disease population with clinical response at baseline)

It is very uncertain whether subcutaneous CT‐P13 and purine analogues changes loss of clinical response (at 22 weeks, less than 100 points in CDAI… compared with intravenous CT‐P13 and purine analogues (very low certainty).

1 finding from 1 review

Subcutaneous CT‐P13 and purine analogues vs intravenous CT‐P13 and purine analogues

Withdrawals due to adverse events · patients with Crohn's disease (active disease population with clinical response at baseline)

It is very uncertain whether subcutaneous CT‐P13 and purine analogues changes withdrawal due to adverse events (at 30 weeks) compared with intravenous CT‐P13 and purine analogues (very low certainty).

1 finding from 1 review

Infliximab vs adalimumab

Loss of clinical response (at 22 weeks, less than 100 points in CDAI change) · patients with Crohn's disease (active disease population with clinical response at baseline)

It is very uncertain whether infliximab changes loss of clinical response (at 56 weeks, less than 100 points in CDAI… compared with adalimumab (very low certainty).

1 finding from 1 review