Findings

What do systematic reviews say?

32 questions · 33 findings · 6 reviews · Headline outcomes only

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No studies found 3 · 9.1%GRADE not reported 1 · 3%Very low 12 · 36.4%Low 15 · 45.5%Moderate 2 · 6.1%High 0 · 0%

Psychological therapies vs other antidepressants

Short‐term remission · adults with panic disorder

It is very uncertain whether all psychological therapies changes short‐term remission compared with other antidepressants (very low certainty).

1 finding from 1 review

Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
RR 0.9 [0.48, 1.67]
3 studies · 135 participants
Very low

Psychological therapies vs other antidepressants

Short‐term response · adults with panic disorder

All psychological therapies showed no clear difference in short‐term response compared with other antidepressants (low certainty).

1 finding from 1 review

Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
RR 0.96 [0.67, 1.37]
3 studies · 128 participants
Low

Psychological therapies vs other antidepressants

Leaving the study early · adults with panic disorder

All psychological therapies showed no clear difference in dropouts for any reason compared with other antidepressants (low certainty).

1 finding from 1 review

Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
RR 1.55 [0.91, 2.65]
3 studies · 180 participants
Low

Psychological therapies vs other antidepressants

Long‐term remission/response · adults with panic disorder

1 finding from 1 review

Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Psychological therapies vs other antidepressants

Short‐term improvement Scale used (range; lower is better): Panic Disorder Severity Scale (0 to 28) Symptom Checklist‐90‐Revised Global Severity · adults with panic disorder

1 finding from 1 review

Psychological therapies versus pharmacological interventions for panic disorder with or without agoraphobia in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 27 participants
Moderate

SSRIs or SNRIs vs other antidepressants

Headache duration (hours) · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 152 participants
Low

SSRIs or SNRIs vs other antidepressants

Symptomatic/analgesic medication use for acute headache attacks · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 152 participants
Low

SSRIs or SNRIs vs other antidepressants

Headache index · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 152 participants
Very low

SSRIs or SNRIs vs other antidepressants

Quality of life · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

SSRIs or SNRIs vs other antidepressants

Withdrawals due to adverse events · patients with tension‐type headache

SSRIs or SNRIs showed no clear difference in withdrawals due to adverse events compared with other antidepressants (low certainty).

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
OR 1.04 [0.41, 2.6]
4 studies · 257 participants
Low

SSRIs or SNRIs vs other antidepressants

Headache (frequency) · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 152 participants
Very low

SSRIs or SNRIs vs other antidepressants

Headache intensity (mean score) · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 152 participants
Very low