Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,721 questions · 19,640 findings · 2,039 reviews · Headline outcomes only

No studies found 3,754 · 19.1%GRADE not reported 1,273 · 6.5%Very low 4,859 · 24.7%Low 5,568 · 28.4%Moderate 3,240 · 16.5%High 946 · 4.8%

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Heparin vs normal saline solution locking

Occlusion of CVC (combining participant and catheter as unit of analysis) Blood withdrawing · adults with CVCs

Heparin may leads to lower occlusion of CVC (combining participant, and catheter as unit of… compared with normal saline solution locking (low certainty).

1 finding from 1 review

Heparin vs normal saline solution locking

CVC‐related bloodstream infections (positive microbiological culture, participant as unit of analysis) · adults with CVCs

It is very uncertain whether heparin changes CVC‐related bloodstream infections (positive microbiological… compared with normal saline solution locking (very low certainty).

1 finding from 1 review

Vitamin A vs placebo or usual care

Diarrhoea incidence Mean episodes per child per year · children aged between 6 months and 5 years

Vitamin A supplementation may leads to lower diarrhoea incidence Mean episodes per child per year compared with placebo or usual care (low certainty).

1 finding from 1 review

Vitamin A vs placebo or usual care

Measles incidence Mean episodes of measles per child per year · children aged between 6 months and 5 years

Vitamin A supplementation probably leads to lower measles incidence Mean episodes of measles per child per year compared with placebo or usual care (moderate certainty).

1 finding from 1 review

Guidewire‐assisted cannulation vs contrast‐assisted cannulation

Post‐ERCP pancreatitis · Patients undergoing diagnostic or therapeutic ERCP

Guidewire‐assisted cannulation probably leads to lower post‐ERCP pancreatitis (PEP) compared with contrast‐assisted cannulation (moderate certainty).

1 finding from 1 review

Guidewire‐assisted cannulation vs contrast‐assisted cannulation

Primary cannulation success · Patients undergoing diagnostic or therapeutic ERCP

Guidewire‐assisted cannulation may leads to higher primary cannulation success compared with contrast‐assisted cannulation (low certainty).

1 finding from 1 review