Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,710 questions · 14,842 findings · 1,394 reviews

No studies found 2,880 · 19.4%GRADE not reported 1,413 · 9.5%Very low 3,103 · 20.9%Low 3,870 · 26.1%Moderate 2,663 · 17.9%High 913 · 6.2%

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Ketamine vs placebo

Efficacy: number of participants who respond to treatment ‐ at 24 hours · adults (aged 18 years+) with depression in bipolar disorder

Ketamine may leads to higher efficacy: number of participants who respond to treatment ‐ at 24… compared with placebo (low certainty).

1 finding from 1 review

Memantine vs placebo

Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder

It is very uncertain whether memantine changes efficacy: number of participants who respond to treatment ‐ at 1 week compared with placebo (very low certainty).

4 findings from 1 review
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Cytidine vs placebo

Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder

It is very uncertain whether cytidine changes efficacy: number of participants who respond to treatment ‐ at 3… compared with placebo (very low certainty).

1 finding from 1 review