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What do systematic reviews say?

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Evidence found and GRADE certainty

4,072 questions · 4,237 findings · 447 reviews · Headline outcomes only

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No studies found 946 · 22.3%GRADE not reported 257 · 6.1%Very low 1,121 · 26.5%Low 1,207 · 28.5%Moderate 568 · 13.4%High 138 · 3.3%

Laparoscopic fundoplication vs medical management

Serious adverse events · Patients with gastro‐oesophageal reflux disease (GORD) in adults

It is very uncertain whether laparoscopic fundoplication changes serious adverse events compared with medical management (very low certainty).

1 finding from 1 review

Laparoscopic fundoplication vs medical management

(5 years or more) · Patients with gastro‐oesophageal reflux disease (GORD) in adults

It is very uncertain whether laparoscopic fundoplication changes (5 years or more) compared with medical management (very low certainty).

1 finding from 1 review

Trapeziectomy with ligament reconstruction and tendon interposition (T and LRTI) vs trapeziectomy and ligament reconstruction (T and LR)

Adverse events Complications reported · Patients with thumb (trapeziometacarpal joint) osteoarthritis

Trapeziectomy with ligament reconstruction and tendon interposition… showed no clear difference in adverse events Complications reported compared with trapeziectomy and ligament reconstruction (T and LR) (low certainty).

1 finding from 1 review