Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,667 questions · 21,760 findings · 2,177 reviews

No studies found 4,173 · 19.2%GRADE not reported 2,300 · 10.6%Very low 5,276 · 24.2%Low 5,764 · 26.5%Moderate 3,298 · 15.2%High 949 · 4.4%

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Chlorhexidine vs Essential oils/herbal mouthwash

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them

Chlorhexidine (CHX) led to lower reduction in level of contamination by particles >5 um (droplets) at… compared with essential oils/herbal mouthwash; GRADE not reported.

4 findings from 1 review
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Essential oil mouthwash vs Coloured and flavoured 5% hydroalcohol mouthwash

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them
1 finding from 1 review

Povidone iodine vs Ozonated water

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them

It is very uncertain whether povidone iodine changes reduction in level of contamination by particles >5 um (droplets) at… compared with ozonated water (very low certainty).

1 finding from 1 review

Chlorhexidine vs Cetylpyridinium chloride (CPC)

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them

It is very uncertain whether chlorhexidine (CHX) changes reduction in level of contamination by particles >5 um (droplets) at… compared with cetylpyridinium chloride (CPC) (very low certainty).

9 findings from 1 review
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Chlorhexidine vs Water (distilled)

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them
5 findings from 1 review
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Cetylpyridinium chloride (CPC) vs No rinsing

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them

It is very uncertain whether cetylpyridinium chloride (CPC) changes reduction in level of contamination by particles >5 um (droplets) at… compared with no rinsing (very low certainty).

3 findings from 1 review

Fluoride-releasing resin-based sealant vs No sealant (control/no treatment)

Development of >=1 new carious lesion (caries incidence) · Children with caries-free or non-cavitated carious lesion primary molars, aged 3-7 years (paediatric department, dental hospital, France)
2 findings from 1 review

Chlorhexidine vs povidone‐iodine

Reduction in level of contamination by particles <=5 um (droplet nuclei) at >=2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them

It is very uncertain whether chlorhexidine (CHX) changes reduction in level of contamination by particles <=5 um (droplet… compared with povidone iodine (very low certainty).

2 findings from 1 review

Tempered cetylpyridinium chloride vs Cold cetylpyridinium chloride

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them

It is very uncertain whether tempered cetylpyridinium chloride changes reduction in level of contamination by particles >5 um (droplets) at… compared with cold cetylpyridinium chloride (very low certainty).

2 findings from 1 review

Glass ionomer-based sealant vs No sealant (control/no treatment)

Development of >=1 new carious lesion (caries incidence) · Children with caries-free primary first molars (with or without caries on other teeth), aged 1-5 years (paediatric clinic/dental school,…

Glass ionomer-based sealant may leads to lower development of >=1 new carious lesion (caries incidence) compared with no sealant (low certainty).

2 findings from 1 review

Oral care vs No oral care

Outcome not reported · Residents of nursing homes and other long-term care facilities

The review found no eligible studies for this question.

1 finding from 1 review

Boric acid vs Water

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them

It is very uncertain whether boric acid changes reduction in level of contamination by particles >5 um (droplets) at… compared with water (very low certainty).

2 findings from 1 review

Chlorhexidine vs Ozonated water

Reduction in level of contamination by particles >5 um (droplets) at <2 m from patient's oral cavity · Dental patients undergoing aerosol-generating procedures (AGPs) and the dental healthcare providers treating them

It is very uncertain whether chlorhexidine (CHX) changes reduction in level of contamination by particles >5 um (droplets) at… compared with ozonated water (very low certainty).

1 finding from 1 review

Fluoride-releasing resin-based sealant vs No sealant (control/no treatment)

Mean caries increment (mean number of new cavitated occlusal lesions) · Children with caries-free or non-cavitated carious lesion primary molars, aged 3-7 years (paediatric department, dental hospital, France)
1 finding from 1 review
  • Sealants for preventing dental caries in primary teeth 2022 · Cochrane All outcomes
    24 months
    Mean number of new cavitated occlusal lesions 0.23 (SD 0.06) in sealed molars vs 0.29 (SD 0.06) in control molars (Wilcoxon matched-pairs signed-rank test P = 0.42)
    1 study · 85 participants
    GRADE not reported

Periodontal treatment: scaling and root planing (SRP) plus advice vs Community care: advice only

All CVD-related death · Patients with cardiovascular disease and chronic periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Professional oral care vs Usual oral care

Incidence of NHAP · Residents of nursing homes and other long-term care facilities
1 finding from 1 review
  • Incidence of NHAP, follow-up 8-30 months, 5018 (5 studies), Low. Not pooled (individual and cluster-randomised designs, varying effect measures and follow-up). Component estimates: Bourigault HR 0.65 (0.29 to 1.46;…
    5 studies · 5018 participants
    Low

Professional oral care vs Usual oral care

Mortality (all‐cause) · Residents of nursing homes and other long-term care facilities
1 finding from 1 review
  • All-cause mortality, follow-up 12-30 months, 3764 (3 studies), Very low. Not pooled. Adachi RR 0.80 (0.40 to 1.58; 88); Juthani-Mehta HR 1.16 (0.88 to 1.53; 834); Zimmerman adjusted IRR 0.83 (0.61 to 1.12; 1606).…
    3 studies · 3764 participants
    Very low

Periodontal treatment: scaling and root planing (SRP) plus advice vs Community care: advice only

Cardiovascular events · Patients with cardiovascular disease and chronic periodontitis
1 finding from 1 review