Clinical Global Impressions scale change item (CGI‐I): no. of responders (long term) Post‐treatment: 1‐4 months · adults with trichotillomania
It is very uncertain whether TCAs with predominantly SRI actions changes treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (very low certainty).
1 finding from 1 review
Reduction of TTM symptom severityNIMH Trichotillomania Severity Scale (NIMH‐TSS) · adults with trichotillomania
1 finding from 1 review
Dropouts due to adverse events · adults with trichotillomania
It is very uncertain whether TCAs with predominantly SRI actions changes tolerability of treatment ‐ dropouts due to adverse eventsdDropout… compared with placebo (very low certainty).
1 finding from 1 review
Treatment responseaPhysician‐rated Clinical Progress Scale · adults with trichotillomania
1 finding from 1 review
Reduction of TTM symptom severityNIMH Trichotillomania Severity Scale (NIMH‐TSS) · adults with trichotillomania
1 finding from 1 review
Withdrawals due to adverse events · adults with trichotillomania
1 finding from 1 review
Withdrawals due to adverse events · adults with trichotillomania
1 finding from 1 review
Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · children with trichotillomania
Antioxidants showed no clear difference in treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (low certainty).
1 finding from 1 review
Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · children with trichotillomania
1 finding from 1 review
Withdrawals due to adverse events · children with trichotillomania
1 finding from 1 review
Global Impressions scale change item (CGI‐I or similar): no. of responders (acute phase) · adults with trichotillomania
Antipsychotics may leads to higher treatment responseaClinical Global Impressions ‐ Improvement Scale… compared with placebo (low certainty).
1 finding from 1 review
Reduction of TTM symptom severityMassachusetts General Hospital Hair‐Pulling Scale (MGH‐HPS) · adults with trichotillomania
1 finding from 1 review
Withdrawals due to adverse events · adults with trichotillomania
1 finding from 1 review
50% or greater reduction in seizure frequency · adults and children with drug‐resistant focal epilepsy
Any dose of lacosamide leads to higher 50% or greater reduction in seizure frequency compared with placebo (high certainty).
1 finding from 1 review
Seizure freedom · adults and children with drug‐resistant focal epilepsy
Any dose of lacosamide may leads to higher seizure freedom compared with placebo (low certainty).
1 finding from 1 review
Treatment withdrawal · adults and children with drug‐resistant focal epilepsy
Any dose of lacosamide probably leads to higher treatment withdrawal compared with placebo (moderate certainty).
1 finding from 1 review
Dizziness · adults and children with drug‐resistant focal epilepsy
Any dose of lacosamide leads to higher dizziness compared with placebo (high certainty).
1 finding from 1 review
Headache · adults and children with drug‐resistant focal epilepsy
Any dose of lacosamide probably leads to higher headache compared with placebo (moderate certainty).
1 finding from 1 review
Vomiting · adults and children with drug‐resistant focal epilepsy
Any dose of lacosamide probably leads to higher vomiting compared with placebo (moderate certainty).
1 finding from 1 review
Serious adverse events · adults and children with drug‐resistant focal epilepsy
Any dose of lacosamide probably leads to higher serious adverse events compared with placebo (moderate certainty).
1 finding from 1 review