Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,703 questions · 15,007 findings · 1,416 reviews

No studies found 2,881 · 19.2%GRADE not reported 1,551 · 10.3%Very low 3,111 · 20.7%Low 3,881 · 25.9%Moderate 2,669 · 17.8%High 914 · 6.1%

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Coenzyme Q10 vs placebo or conventional therapy

Heart failure hospitalisation (RR) · patients with heart failure

Coenzyme Q10 probably leads to lower hospitalisation for heart failure compared with placebo or conventional therapy (moderate certainty).

1 finding from 1 review

Any dose of lacosamide vs placebo

50% or greater reduction in seizure frequency · adults and children with drug‐resistant focal epilepsy

Any dose of lacosamide leads to higher 50% or greater reduction in seizure frequency compared with placebo (high certainty).

1 finding from 1 review