What do systematic reviews say?

Beta‐blockers vs calcium channel blockers

Beta‐blockers showed no clear difference in withdrawal due to adverse effect compared with calcium‐channel blockers (low certainty).

• Beta‐blockers for hypertension 2017 · Cochrane Headline outcomes only
  RR 1.2 [0.71, 2.04]
  2 studies · 21591 participants
  Low

Beta‐blockers vs renin‐angiotensin system inhibitors

Beta‐blockers showed no clear difference in total mortality compared with renin‐angiotensin system inhibitors (moderate certainty).

• Beta‐blockers for hypertension 2017 · Cochrane Headline outcomes only
  RR 1.1 [0.98, 1.24]
  3 studies · 10828 participants
  Moderate

Beta‐blockers vs renin‐angiotensin system inhibitors

Beta‐blockers showed no clear difference in total cardiovascular disease compared with renin‐angiotensin system inhibitors (low certainty).

• Beta‐blockers for hypertension 2017 · Cochrane Headline outcomes only
  RR 1 [0.72, 1.38]
  3 studies · 10828 participants
  Low

Beta‐blockers vs renin‐angiotensin system inhibitors

Beta‐blockers probably leads to higher total stroke compared with renin‐angiotensin system inhibitors (moderate certainty).

• Beta‐blockers for hypertension 2017 · Cochrane Headline outcomes only
  RR 1.3 [1.11, 1.53]
  2 studies · 9951 participants
  Moderate

Beta‐blockers vs renin‐angiotensin system inhibitors

Beta‐blockers showed no clear difference in total coronary heart disease compared with renin‐angiotensin system inhibitors (low certainty).

• Beta‐blockers for hypertension 2017 · Cochrane Headline outcomes only
  RR 0.9 [0.76, 1.06]
  2 studies · 9951 participants
  Low

Beta‐blockers vs placebo

Beta‐blockers may leads to lower total cardiovascular disease compared with placebo (low certainty).

• Beta‐blockers for hypertension 2017 · Cochrane Headline outcomes only
  RR 0.88 [0.79, 0.97]
  4 studies · 23613 participants
  Low

Beta‐blockers vs renin‐angiotensin system inhibitors

Beta‐blockers probably leads to higher withdrawal due to adverse effect compared with renin‐angiotensin system inhibitors (moderate certainty).

• Beta‐blockers for hypertension 2017 · Cochrane Headline outcomes only
  RR 1.41 [1.29, 1.54]
  2 studies · 9951 participants
  Moderate

Beta‐blockers vs placebo

Beta‐blockers may leads to lower total stroke compared with placebo (low certainty).

• Beta‐blockers for hypertension 2017 · Cochrane Headline outcomes only
  RR 0.8 [0.66, 0.96]
  4 studies · 23613 participants
  Low

Beta‐blockers vs placebo

Beta‐blockers showed no clear difference in total coronary heart disease compared with placebo (moderate certainty).

• Beta‐blockers for hypertension 2017 · Cochrane Headline outcomes only
  RR 0.93 [0.81, 1.07]
  4 studies · 23613 participants
  Moderate

Beta‐blockers vs placebo

Beta‐blockers showed no clear difference in withdrawal due to adverse effect compared with placebo (low certainty).

• Beta‐blockers for hypertension 2017 · Cochrane Headline outcomes only
  RR 3.38 [0.82, 13.95]
  3 studies · 22729 participants
  Low

Beta‐blockers vs diuretics

Beta‐blockers showed no clear difference in total mortality compared with diuretics (moderate certainty).

• Beta‐blockers for hypertension 2017 · Cochrane Headline outcomes only
  RR 1.04 [0.91, 1.19]
  5 studies · 18241 participants
  Moderate

Beta‐blockers vs diuretics

Beta‐blockers showed no clear difference in total cardiovascular disease compared with diuretics (moderate certainty).

• Beta‐blockers for hypertension 2017 · Cochrane Headline outcomes only
  RR 1.13 [0.99, 1.28]
  4 studies · 18135 participants
  Moderate

Beta‐blockers vs diuretics

Beta‐blockers showed no clear difference in total stroke compared with diuretics (low certainty).

• Beta‐blockers for hypertension 2017 · Cochrane Headline outcomes only
  RR 1.17 [0.65, 2.09]
  4 studies · 18135 participants
  Low

Beta‐blockers vs diuretics

Beta‐blockers showed no clear difference in total coronary heart disease compared with diuretics (low certainty).

• Beta‐blockers for hypertension 2017 · Cochrane Headline outcomes only
  RR 1.12 [0.82, 1.54]
  4 studies · 18135 participants
  Low

Intervention not reported

• Blood pressure lowering efficacy of renin inhibitors for primary hypertension 2017 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 1100 participants
  Moderate

Intervention not reported

• Blood pressure lowering efficacy of renin inhibitors for primary hypertension 2017 · Cochrane Headline outcomes only
  no estimate extracted
  12 studies · 3786 participants
  Moderate

Intervention not reported

• Blood pressure lowering efficacy of renin inhibitors for primary hypertension 2017 · Cochrane Headline outcomes only
  no estimate extracted
  10 studies · 3009 participants
  Moderate

Intervention not reported

• Blood pressure lowering efficacy of renin inhibitors for primary hypertension 2017 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 393 participants
  Low

Intervention not reported

• Blood pressure lowering efficacy of renin inhibitors for primary hypertension 2017 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 1100 participants
  Moderate

Intervention not reported

• Blood pressure lowering efficacy of renin inhibitors for primary hypertension 2017 · Cochrane Headline outcomes only
  no estimate extracted
  12 studies · 3783 participants
  Moderate