Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

411 questions · 420 findings · 42 reviews

No studies found 99 · 23.6%GRADE not reported 35 · 8.3%Very low 135 · 32.1%Low 114 · 27.1%Moderate 34 · 8.1%High 3 · 0.7%

Intervention not reported

Diarrhoea lasting ≥ 48 hours · children and adults with acute infectious diarrhoea

The intervention showed no clear difference in diarrhoea lasting ≥ 48 hours (moderate certainty).

1 finding from 1 review

Intervention not reported

Mean duration of diarrhoea (hours) · children and adults with acute infectious diarrhoea
1 finding from 1 review

Probiotic + 5‐aminosalicylic acid (5‐ASA) (mesalazine) vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Clinical relapse · Patients with quiescent ulcerative colitis

It is very uncertain whether probiotic + 5‐aminosalicylic acid (5‐ASA) (mesalazine) changes clinical relapse (12 to 52 weeks) compared with 5‐ASA (mesalazine) (very low certainty).

1 finding from 1 review

Probiotic + 5‐aminosalicylic acid (5‐ASA) (mesalazine) vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Maintenance of clinical remission · Patients with quiescent ulcerative colitis

Probiotic + 5‐aminosalicylic acid (5‐ASA) (mesalazine) showed no clear difference in maintenance of clinical remission (24 to 52 weeks) compared with 5‐ASA (mesalazine) (low certainty).

1 finding from 1 review

Probiotic + 5‐aminosalicylic acid (5‐ASA) (mesalazine) vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Withdrawals due to adverse events · Patients with quiescent ulcerative colitis

It is very uncertain whether probiotic + 5‐aminosalicylic acid (5‐ASA) (mesalazine) changes withdrawal due to adverse events (12 to 52 weeks) compared with 5‐ASA (mesalazine) (very low certainty).

1 finding from 1 review

Intervention not reported

Incidence of AAD · Children receiving antibiotic treatment between 4 and 28 days duration for a variety of infections

The intervention probably leads to lower incidence of AAD (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events · Children receiving antibiotic treatment between 4 and 28 days duration for a variety of infections

The intervention showed no clear difference in adverse events (low certainty).

1 finding from 1 review

Probiotics vs placebo

Proportion of children with AOM (overall) · children up to age 18 years

Probiotic probably leads to lower proportion of children with AOM (overall) compared with placebo (moderate certainty).

1 finding from 1 review